Hla mus rau cov ntsiab lus

Cov Pauv Nyiaj


Ishmail Abdus-Saboor, Ph.D., Assistant Professor, Biological Sciences and the Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY

Skin-Brain Axis for Rewarding Touch Behaviors

Social touch is a key stimulus that is foundational to human experiences ranging from nurturing others and building social bonds to sexual receptivity. Working with a mouse model and optogenetics, Abdus-Saboor’s previous research has shown that there are direct connections between skin neural cells and the brain, and that dedicated cells are specifically tuned to certain touch cues. These cells are necessary and sufficient to elicit specific physical responses.

In his new research, Abdus-Saboor and his team aim to define how neurons in the skin trigger unique positive signals in the brain, and how the brain receives and processes those signals as rewarding, as well as identifying touch neurons that are required in different touch scenarios (nurturing pups vs. grooming or play). A third aim will seek to identify what sensor on these cells identifies touch. The research will reveal more about the skin-brain connection, with potential applications for researchers studying social disorders.

Yasmine El-Shamayleh, Ph.D., Assistant Professor, Department of Neuroscience & Zuckerman Mind Brain Behavior Institute, Columbia University, New York City, NY

Cortical Circuits for Perceiving Visual Form

In primates, roughly 30% of the cerebral cortex is dedicated to processing visual information. Using new techniques, Dr. El-Shamayleh is working toward developing a detailed mechanistic understanding of how the brain detects and recognizes the objects we see. Focusing on cortical area V4, El-Shamayleh’s research is revealing how various types of neurons in this brain region support our ability to perceive the shape of visual objects.

Cortical area V4 is highly attuned to the shape of objects in the world. Building on these key insights and using novel applications of viral vector-based optogenetics, El-Shamayleh is recording and manipulating the activity of specific groups of V4 neurons with unprecedented precision. This research is identifying how various types of neurons in cortical area V4 interact to process an object’s shape and will unlock details about how primate brains process visual information. The technical innovations established in this research will also facilitate future mechanistic studies of primate brain function and behaviors.

Vikram Gadagkar, Ph.D., Assistant Professor, Department of Neuroscience & Zuckerman Mind Brain Behavior Institute, Columbia University, New York City, NY

Neural Mechanisms of Courtship and Monogamy

While there has been significant research into how animals learn and perform behaviors, less attention has been paid to how one animal evaluates the performance of another during social interactions. In songbirds, most research has looked at what happens in the brains of males performing a song to attract a mate, but not what occurs in the female bird’s brain as she listens to male song.

Dr. Gadagkar’s work will look at a part of the brain called HVC, a sensorimotor nucleus known to be active in males to keep time as they learn and perform their song. For the first time, he and his lab are recording what happens in female HVC as she listens and evaluates male song. Second, Dr. Gadagkar will examine how females make their evaluation, and what neurons do when errors are detected. Finally, the research will look at the dopamine system to see how the brain shows a preference for the most attractive performance.

Hidehiko Inagaki, Ph.D., Max Planck Florida Institute for Neuroscience, Jupiter, FL

Synaptic Mechanisms and Network Dynamics Underlying Motor Learning

Learning a new skill requires the brain to make changes to its circuitry, a process known as plasticity. While significant research has been done to identify how brain networks execute the skill, less is understood about the mechanics of learning new skills. Dr. Inagaki and his team are working to zero in on the cells and processes involved during the process of learning.

Using in vivo 2-photon imaging and large-scale electrophysiology in a mouse model, Dr. Inagaki and his team can now watch at the cellular level what changes are happening as a new skill is learned – in this case, learning a new timing for the action. Using genetic manipulation to enable the researchers to activate or inhibit proteins associated with plasticity, they aim to uncover not just what changes in the brain, but how those changes are initiated and consolidated. Understanding more about how learning works could have implications for research into learning impairments.

Peri Kurshan, Ph.D., Assistant Professor, Albert Einstein College of Medicine, Bronx, NY

Unravelling The Mechanisms of Synapse Development, From Molecules to Behavior

Synapses, the places where signals are sent and received between neurons, are the key to the function of neural circuits that underlie behavior. Understanding how synapses develop at the molecular level and how synaptic development influences behavior is the aim of Dr. Kurshan’s research. The dominant model holds that a class of proteins called synaptic cell-adhesion molecules (sCAMs) initiate the process, with a family of sCAMs called neurexins especially indicated. But in vivo research shows that knocking out neurexins does not eliminate synapses.

Dr Kurshan’s work indicates that presynaptic cytosolic scaffold proteins may self-associate with the cell membrane, and then subsequently recruit neurexins to stabilize synapses. In her new research, using imaging, proteomics, computational modeling, and transgenic manipulation, she and her lab aim to identify what proteins and cell-membrane components are involved and how they interact. The research has implications for a range of neurological disorders that are tied to synaptic defects.

Scott Linderman, Ph.D., Assistant Professor, Statistics and Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA

Machine Learning Methods for Discovering Structure in Neural and Behavioral Data

Dr. Linderman’s contributions to neuroscience lie in developing machine learning methods that can manage and extract insights from the staggering amounts of data these kinds of research produce, such as high-resolution recordings of large numbers of neurons across the brain and simultaneously observing behaviors of freely behaving animals over long timeframes. Linderman and his team partner with research labs to develop probabilistic machine learning methods to find patterns in all that data.

Linderman’s lab is focused specifically on computational neuroethology and probabilistic modeling – essentially, figuring out how to construct and fit statistical models to the kind of data researchers produce today. His ongoing and future projects demonstrate the breadth of ways machine learning can be applied to neural research. Linderman approaches the work as an integrated partner with experimental collaborators, and by developing methods to solve the problems of neurobiology is also helping advance the fields of statistics and machine learning.

Swetha Murthy, Ph.D., Assistant Professor, Vollum Institute, Oregon Health and Science University, Portland, OR

Mechanosensation for Guiding Cellular Morphology

Mechanosensation – or the detection of physical force by a cell or a neuron – is a surprisingly subtle and multi-purpose function mediated by certain ion channels (among other proteins) on the cellular membrane. An obvious example is the sense of touch. Dr. Murthy’s lab is digging into a much smaller-scale instance of mechanosensation with profound implications for neural health: The process of myelination, in which specialized cells called oligodendrocytes (OLs) form a sheath around a nerve to improve conduction.

It is hypothesized that mechanical cues (among other factors) can govern OL morphology and myelination, but the underlying mechanisms have remained unknown. Murthy’s lab is studying the mechano-activated ion channel TMEM63A, which is expressed in OLs, to reveal how these channels could mediate myelination and in turn shed light on how mechanical cues guide the process. Understanding how myelination can work – and how it can fail – will be helpful to researchers studying a range of conditions tied to myelination.

Karthik Shekhar, Ph.D., Chemical and Biomolecular Engineering/ Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA

Evolution of Neural Diversity and Patterning in the Visual System

Dr. Shekhar’s lab seeks to understand how diverse neural types and their organization evolved to serve the needs of different animals. His research focuses on the visual system of the brain, specifically the retina and the primary visual cortex, which are remarkably well conserved across species separated by hundreds of millions of years of evolution.

Shekhar’s research will examine the evolutionary conservation and divergence of neuronal types in the retina of several vertebrate species, from fish to birds to mammals, and use computational approaches to reconstruct the evolution of neural diversity, including whether evolution led to the rise of new types or modification of existing types. A concurrent effort will investigate the visual cortex and trace the origins of early developmental epochs known as “critical periods”, where neural networks in the brain show exquisite plasticity to sensory experience. A guiding principle underlying Shekhar’s approach is that interdisciplinary collaborations can bring new approaches to tackle big questions in neuroscience.

Tanya Sippy, Ph.D., Assistant Professor, New York University Grossman School of Medicine, New York City, NY

Modulation of Striatal Cells and Synapses by Dopamine Movement Signals

Dopamine is perhaps the most widely known neuromodulator, largely due to the role it plays in signaling reward. However, dopamine also plays a key role in movement, which is clearly demonstrated by the inability of patients with Parkinson’s Disease, a disorder of dopamine, to initiate movements. Dr. Sippy aims to help learn more about how dopamine is involved in movement, through very precise in vivo measurements of dopamine fluctuations simultaneously with the membrane potential in target neurons.

Membrane potential recordings allow Dr. Sippy’s lab members to measure two properties of neurons that are known to be affected by neuromodulation: 1) the strength of synaptic inputs and 2) the excitability of the neurons that determines how they respond to these inputs. But measuring both dopamine fluctuations and membrane potential in one cell is very hard. Sippy’s work hinges on the discovery that dopamine activity is mirrored in the two hemispheres of the brain, and so measurement of it and membrane potential can be made on opposite sides and still have strongly correlated results. With these recordings made, Sippy will optogenetically manipulate the dopamine system and see how activating or suppressing dopamine affects the properties of target neurons, and how this affects the actions of the animal.

Moriel Zelikowsky, Ph.D., Assistant Professor, University of Utah, Salt Lake City, UT

Neuropeptidergic Cortical Control of Social Isolation

Prolonged social isolation can negatively impact mammalian life, including a steep rise in aggression. While many studies have looked at subcortical control of natural forms of aggression, few have looked at pathological forms of aggression or their top-down control. Dr. Zelikowsky aims to better understand the mechanism and cortical circuits involved in the rise of aggression as a result of chronic social isolation.

Initial research using a mouse model identified a role for the neuropeptide Tachykinin 2 (Tac2) as a subcortical neuromodulator of isolation-induced fear and aggression. Critically, Tac2 was also found to be upregulated in the medial prefrontal cortex (mPFC) after social isolation. Zelikowsky’s research uses cell-type specific perturbations in mice who have experienced social isolation. Machine learning is used to identify clusters of behavior, which are mapped to imaged brain activity. By understanding how isolation can change the brains of mammals, future researchers may be able to better understand the effects of extended social deprivation in humans.


Christine Constantinople, Ph.D., Assistant xibfwb, New York University Center rau Neural Science, New York City, NY

Neural Circuit Mechanisms ntawm Inference

Dr. Constantinople tab tom ua haujlwm nrog tus qauv nas txhawm rau nthuav tawm qhov twg ntawm lub hlwb tau koom nrog hauv kev cuam tshuam txog lub ntiaj teb thiab seb cov neurons tuaj sawv cev li cas hauv ntiaj teb, thiab qhov sib txawv ntawm lub paj hlwb ntawm kev txiav txim siab hauv qhov chaw tsis meej lossis poob. rov qab rau qhov kev coj cwj pwm. Qhov kev sim no suav nrog tos kom tau txais txiaj ntsig dej paub, lossis "tso tawm" hauv kev cia siab tias qhov khoom plig tom ntej muaj txiaj ntsig zoo dua.

Los ntawm kev saib xyuas lub hlwb ua haujlwm hauv ntau thaj tsam thiab hauv qhov kev kwv yees tshwj xeeb thaum lub sijhawm kwv yees thiab tsis muaj kev cia siab thiab kev hloov pauv ntawm lawv, thiab ua kom tsis muaj zog ntawm lub hlwb thiab txoj hauv kev neural hauv kev sim sib txawv, Dr. Constantine thov kom txheeb xyuas cov txheej txheem koom nrog hauv kev xav. Nws tawm tswv yim tias cov txheej txheem sib txawv muaj feem cuam tshuam thaum xaiv qhov kev txiav txim raws li tus qauv kev xav thiab kev txiav txim siab tsis pub tus qauv; uas txawv thalamic nuclei encode cov khoom plig thiab nas keeb kwm cais; thiab hais tias lub orbitofrontal cortex (OFC) integrates ob qhov sib tshooj tab sis txawv inputs infer tsis paub lub xeev.

Bradley Dickerson, Ph.D., Assistant xibfwb, Princeton Neuroscience Institute, Princeton University, Princeton, NJ

Proportional-Integral Feedback hauv Biological 'Gyroscope'

Lub paj hlwb sau thiab ua rau cov ntaub ntawv nkag hauv milliseconds - qee zaum nrog cov kab mob nyuaj, qee zaum nrog lub hom phiaj. Dr. Dickerson thov kom daws tau cov theem ntawm kev tswj cov txiv hmab txiv ntoo yoov muaj dhau ntawm qee cov leeg nqaij sib dhos los ntawm ib qho kev sim uas kawm tshwj xeeb hauv lub cev mechanosensory tshwj xeeb rau cov yoov hu ua halteres, uas ua raws li cov khoom siv gyroscope.

Dr. Dickerson qhia tias lub haltere muaj cais tswj cov txheej txheem uas tuaj yeem nrhiav tau thaum muaj kev cuam tshuam los muab cov yoov tshaj plaws tswj. Hauv kev tswj hwm engineering lingo, nws ntseeg hais tias lub haltere tuaj yeem cuam tshuam rau ob qho tib si sib npaug (qhov loj ntawm kev cuam tshuam) thiab ib qho (yuav ua li cas qhov kev cuam tshuam hloov pauv lub sijhawm) cov lus tawm tswv yim - qhov kev xav zoo dua li yav tas los ntseeg. Siv lub tshuab ntsuas epiflourescent, ob-photon microscope saum tus yoov los saib xyuas lub hlwb kev ua haujlwm, thiab lub koob yees duab hauv qab taug qab tis tis, nws yuav taug qab qhov tshwm sim hauv cov neurons thiab cov leeg nqaij thaum yoov tau nthuav tawm nrog kev pom kev pom. Nws vam tias yuav tsim ib qho qauv ntawm yuav ua li cas lub hlwb, neurons, thiab cov leeg sib txuas lus uas tuaj yeem ua rau peb nkag siab txog kev tswj hwm kev txav mus los.

Markita Landry, Ph.D., Assistant xibfwb, University of California - Berkeley, Department of Chemical and Biomolecular Engineering, Berkely, CA

Illuminating Oxytocin Signaling nyob rau hauv lub hlwb nrog ze-Infrared Fluorescent Nanosensors

Dr. Landry txoj haujlwm suav nrog kev tsim "optical probes" - cov pa roj carbon nanotubes miniscule nrog peptide khi rau saum npoo uas yuav fluoresce nyob ze-infrared teeb thaum muaj oxytocin hauv lub hlwb. Qhov fluorescence no tuaj yeem kuaj pom nrog qhov tseeb siab ntawm lub sijhawm millisecond, cia cov kws tshawb fawb pom qhov twg thiab thaum twg nws nyob hauv lub hlwb, thiab yog li txheeb xyuas raws li cov xwm txheej oxytocin tso tawm tuaj yeem cuam tshuam (thiab yog li kho tau) hauv kev xav, cwj pwm, thiab kev sib raug zoo. tsis meej pem.

Qhov tseem ceeb, cov nanotubes no tuaj yeem nkag mus rau hauv cov ntaub so ntswg hlwb sab nraud; cov fluorescence tsis yog qhov tshwm sim ntawm genetic encoding, yog li nws tuaj yeem siv rau ntawm cov tsiaj uas tsis tau hloov kho. Vim tias lawv tawm lub teeb ze-infrared, nws muaj peev xwm pom tau tias lub teeb tuaj yeem pom los ntawm lub cranium, uas yuav ua rau muaj kev cuam tshuam tsawg heev rau cov khoom. Nrog cov sensors no ua ib lub cuab yeej, Dr. Landry cia siab tias yuav pab txhim kho kev kuaj mob ntawm cov hlab ntsha hauv lub paj hlwb thiab yog li destigmatize thiab txhim kho kev kho mob ntawm ntau yam mob.

Lauren Orefice, Ph.D., Massachusetts General Tsev Kho Mob / Harvard Medical School, Boston, MA

Kev loj hlob, kev ua haujlwm, thiab kev ua haujlwm tsis zoo ntawm Somatosensory thiab Viscerosensory Systems hauv Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) ib txwm xav tias tsuas yog tshwm sim los ntawm qhov txawv txav hauv lub hlwb, tab sis hauv nws txoj kev tshawb fawb, Dr. Orefice tau pom tias kev hloov pauv hauv peripheral sensory neurons ua rau muaj kev loj hlob ntawm ASD cov tsos mob hauv cov nas, nrog rau kev hnov mob rau kov. ntawm daim tawv nqaij thiab hloov kev coj cwj pwm. Nws txoj kev tshawb fawb tam sim no yuav tsom mus rau seb puas muaj cov peripheral sensory neurons ntawm dorsal cag ganglia (DRG) uas ntes cov stimuli hauv plab hnyuv kuj yog qhov txawv txav hauv cov qauv nas rau ASD, thiab nkag siab tias yuav hloov pauv li cas hauv kev loj hlob ntawm somatosensory circuit vim peripheral sensory neuron dysfunction ua rau. hloov mus rau kev sib txuas ntawm lub hlwb circuits uas tswj lossis hloov kev coj cwj pwm.

Thaum kawg, Dr. Orefice yuav tsom mus rau kev txhais nws cov kev tshawb pom los ntawm kev tshawb fawb nas preclinical kom nkag siab txog ASD-txog qhov teeb meem ntawm tib neeg. Dr. Orefice yuav ua ntej kuaj seb txoj hauv kev uas txo cov peripheral sensory neuron excitability tuaj yeem txhim kho kev kov dhau-reactivity thiab teeb meem plab hnyuv hauv nas. Nws yuav siv cov kev tshawb pom no hauv cov nas kom nkag siab zoo dua tib neeg lub cev siv cov kev tshawb fawb ntawm cov kab lis kev cai coj los ntawm cov neeg muaj ASD.

Kanaka Rajan, Ph.D., Associate Professor, Department of Neurobiology, Blavatnik Institute, Harvard Medical School; Faculty, Kempner Institute for the Study of Natural and Artificial Intelligence, Harvard University

Multiscale Neural Network Models rau Infer Functional Motifs nyob rau hauv lub hlwb

Dr. Rajan tab tom siv lub zog ntawm AI-raws li qauv los ua kom zoo dua, muaj kev kwv yees ntau dua ntawm lub hlwb. Siv cov qauv neural network recurrent (RNNs), Dr. Rajan tau tshawb pom tias muab cov kev txwv ntau dua ntawm cov qauv kev suav ua rau muaj kev tshawb pom zoo sib xws thiab qhov chaw me me, muaj zog dua. Txij li thaum nws tau tig los tsim ntau qhov RNNs qhov twg cov kev txwv yog neural, tus cwj pwm, thiab cov ntaub ntawv anatomical los ntawm kev sim tiag tiag, thiab siv tib lub sijhawm. Nws cov kauj ruam tom ntej yuav yog los tsim ntau qhov RNNs uas siv cov ntaub ntawv sau tseg los ntawm ntau hom kev kawm zoo hauv kev tshawb fawb neuroscience-larval zebrafish, txiv hmab txiv ntoo yoov, thiab nas-los tsim qauv.

Thaum kawg, kev siv cov ntaub ntawv los ntawm ntau hom yuav tso cai rau Dr. Rajan txheeb xyuas "Functional Motifs" thiab siv lawv los tshawb pom qhov sib txawv thiab qhov sib txawv ntawm cov kab ke no. Cov kev sib koom ua ke no, sib cais ntawm cov neurons nquag uas txuas nrog cov cwj pwm zoo sib xws thiab cov xeev, tsis hais hom twg, yuav pab peb kom pom tias lub hlwb ua haujlwm li cas ntawm qib tseem ceeb. Nrog cov ntaub ntawv muaj, cov qauv no tuaj yeem khiav ntau qhov xwm txheej thiab txheeb xyuas qhov kev hloov pauv hauv cov qauv lossis kev ua haujlwm neural ua rau muaj kev coj cwj pwm sib txawv.

Weiwei Wang, Ph.D., Assistant Professor, University of Texas Southwestern Medical Center, Dallas, TX

Nkag siab txog Kev Tsim Kho thiab Kev Ua Haujlwm ntawm Glycinergic Post-Synaptic Assemblies

Txoj kev neurons sib txuas lus nrog ib leeg yog qhov nyuaj heev: neurotransmitters tau dhau los ntawm ib qho neuron mus rau lwm qhov ntawm cov synapses, qhia cov synaptic receptors ntawm cov txais neuron kom qhib thiab tsim cov channel uas tso cai rau ions hla dhau, thiab yog li xa cov teeb liab hluav taws xob. Txawm li cas los xij, yog tias cov synapses tsis ua haujlwm lossis ua tsis tiav, qhov cuam tshuam ntawm cov teeb liab no tuaj yeem ua rau muaj kev puas tsuaj rau lub paj hlwb. Dr. Wang nrhiav kom nthuav dav peb txoj kev nkag siab ntawm cov synapses no, lawv tsim li cas, thiab lawv ua haujlwm li cas - tshwj xeeb, lawv npaj cov synaptic receptors rau hauv pawg li cas, thiab vim li cas nws tseem ceeb uas cov receptors sib sau ua ke hauv cov ntsiab lus siab - los ntawm kev kawm kom ntxaws txog glycinergic. synapse.

Dr. Wang yuav siv cryo-electron microscopy kom paub meej cov qauv molecular ntawm txhua glycinergic synapse sub-hom uas tseem tsis tau raug daws thiab yog li txheeb xyuas seb txhua txoj haujlwm; kuaj seb lub scaffolding uas cov glycine receptors pawg ntawm yog tsim los ntawm cov proteins gephyrin, neuroligin-2, thiab collybistin; thiab thaum kawg sim purified receptors ntawm ib daim nyias nyias, ua ntej nyob rau hauv kev sib cais, ces khi rau lub scaffold, thiab ces khi rau lub scaffold nyob rau hauv ib pawg saib yuav ua li cas cov hauj lwm hloov.


Lucas Cheadle, PhD, Pabcuam Kws Qhia Ntawv, Lub Caij Nplooj Ntoos Hlav Chaw Txias Chaw Nres Nkoj, Chaw Nres Caij Nplooj Ntoos Hlav, NY 

Uncovering Molecular Cov Hauv Paus ntawm Microglial Ua Haujlwm hauv lub Hlwb Hlav

Hauv nws qhov kev tshawb fawb, Dr. Cheadle tab tom kawm txog kev txhim kho qhov muag pom ntawm qhov sib txuas siv nas tus qauv uas qee cov nas tau tu nyob rau qhov chaw tsis muaj teeb meem thaum lub sijhawm tseem ceeb ntawm txoj kev loj hlob. Nws cov kev tshawb fawb yav dhau los qhia tias microglia tseem ceeb "duab puab" lub kaw lus pom, culling synaptic sib txuas uas tsis muaj txiaj ntsig. Raws li qhov tshwm sim, lub cev kom ua raws li ntawm qhov ntawm cov neural uas yog qhov sib txawv hauv cov nas reared hauv maub dua li cov uas tau txais kev pom hauv lub teeb. Hauv nws txoj haujlwm txuas ntxiv, Dr. Cheadle yuav nrhiav kev txheeb xyuas qib theem li hais tias microglia tsa los ntawm lwm yam sab nraud (xws li lub teeb) thiab cov kev teeb tsa uas lawv mam li ua kom cov duab sib hloov.

Cov kev tshawb fawb muaj ntau txoj kev qhia tshiab, suav nrog kev siv cov noob-hloov kho tshuab los tua cov hom microglial kom paub txog lawv lub luag haujlwm hauv kev tsim kho lub voj voos, nrog rau kev tsim cov kab sib hloov ntawm cov nas uas cim cov haujlwm ua haujlwm microglial hlwb hauv lub hlwb, ob leeg kev tawm tsam feem ntau. feem ntau tau thov rau cov neurons uas Dr. Cheadle yoog kom kawm microglia thawj zaug.

Josie Clowney, PhD, Pab xibfwb, University of Michigan, Fai ntawm Molecular, Cellular thiab kev loj hlob Biology, Ann Arbor, MI

Feminist Framing ntawm Txiv Hmab Txiv Ntoo: Maleness raws li Kev Tshaj Tawm ntawm Poj Niam Neural Cov Kev Pab Cuam

Kev tshawb nrhiav ntau qhov sib txawv ntawm qhov sib txawv ntawm txiv neej thiab poj niam lub hlwb tau coj tus cwj pwm, xws li kev ua yeeb yam ntawm kev sib koom tes ntawm kev sib deev, tab sis tsawg dua yog nkag siab txog yuav ua li cas cov noob caj noob uas tsav cov kev ua txhaum raug tso rau hauv lub hlwb. Dr. Clowney suav hais tias cov txheej txheem yog ib qho ntawm kev rho tawm. Nws cov kev tshawb fawb los txog hnub uas siv cov qauv txiv hmab txiv ntoo hais tias txiv neej lub hlwb yuav tshwm sim los ntawm kev tshem tawm cov neural los ntawm "qauv qauv" uas tau ze dua rau tus poj niam lub hlwb, dua li tsim cov kev kawm tshiab.

Qhov tseem ceeb ntawm cov txheej txheem yog cov txiv hmab txiv ntoo hloov chaw hu ua "Txiv hmab txiv ntoo," uas yog cov protein tsim hauv txiv neej cov paj txiv ntoo. Hauv nws qhov kev tshawb fawb, Dr. Clowney yuav ua cov kev sim siv ntau hom tswv yim los soj ntsuam qhov nce lossis ploj ntawm kev sib daj sib deev thiab coj tus cwj pwm hauv cov tsiaj nrog lossis tsis muaj Txiv Hmab Txiv Ntoo.

Shaul Druckmann, PhD, Pabcuam xibfwb ntawm Neurobiology thiab ntawm Psychiatry thiab Cwj Pwm Kev Coj Zoo, Stanford University, Stanford, CA

Lub Hlwb Hlwb Hlwb Siv Tes Taw Ua Tau Cuam Npaum Li Cas Rau Cov Neeg Thiab Lub Hlwb Hlwb?

Tom qab ntau xyoo ntawm kev tshawb fawb, peb tseem muaj kev nkag siab me me txog qhov lub hlwb ua cov kev kwv yees nyob thoob plaws cheeb tsam. Cov lus nug tseem ceeb no yog nyob hauv plawv ntawm Dr. Druckmann kev ua haujlwm, uas tau siv sijhawm ntau ntxiv thiab nthuav dav ntawm lub hlwb kev ua ub no sau cia los tshawb txog dab tsi tshwm sim hauv lub hlwb ntawm kev txhawb nqa thiab teb, tshwj xeeb tshaj yog thaum cov lus teb ncua thiab ncua lub cim xeeb. yog nrog.

Cov ntaub ntawv pib qhia tau hais tias kev ua ub no tam sim no thiab hloov thoob plaws thaj chaw thiab hauv cov neeg sib txawv hauv cov xwm txheej no, thiab Druckmann lub hom phiaj qhia tau tias qhov kev ua ub no sib cuam tshuam thoob plaws thaj chaw hauv lub hlwb thiab cov hauv kev uas cov kev sib cuam tshuam tuaj yeem "kho" qhov tsim nyog nco thiab qhov laj thawj, txawm tias thaum ib cheeb tsam lossis tib neeg cov haujlwm yuav ua yuam kev. Ib lub hom phiaj ntxiv ntawm qhov phiaj xwm yog kom nthuav dav txoj kev tshawb fawb ua haujlwm; nws qhov dej num muaj kev sib koom tes ua ke nrog ntau tus kws tshawb fawb, thiab nws cia siab tias yuav muaj peev xwm tshawb nrhiav ob qho tib si kev tshawb fawb thiab tseem nrhiav kev siv tshuaj rau nws tshawb pom.

Laura Lewis, PhD, Pabcuam xibfwb, Boston University, Chav Lis Haujlwm Feem Txawv Tebchaws Ua Haujlwm, Boston, MA

Kev Ntsuas Neural thiab Nqaij Ua Si hauv lub hlwb pw

Ob lub neural kev ua si thiab cov dej ntws hloov pauv ntawm cerebrospinal kua (CSF) hloov thaum lub sijhawm pw, nrog rau cov kev hloov pauv txawv - lub zog ntawm lub zog hloov pauv ntawm kev paub txog qhov kev xav ntawm sab nraud thiab mus rau lub cim xeeb rov qab, thiab CSF ntws mus rau hauv lub hlwb thiab tshem tawm cov tshuaj lom protein uas txhim tsa thaum lub sijhawm. waking teev. Intriguingly, ob qho txheej txheem tau sib txuam zoo. Hauv nws qhov kev tshawb fawb, Dr. Lewis yuav tshawb xyuas qhov sib txuas ntawm cov leeg ntshav thiab kua dej thaum pw tsaug zog thiab kev sib txuas ntawm txhua tus mus rau lub hlwb kev noj qab haus huv.

Yuav kom ua tau li ntawd, Dr. Lewis tab tom siv txoj hauv kev tshiab los soj ntsuam synchronized, cov haujlwm neural tseeb thiab CSF ntws. Nws cov kev tshawb fawb yuav tshawb pom ua ntej cov yoj qeeb no qhib rau lub hlwb thiab cov kev sib koom tes neural, siv cov kev hnov zoo uas tuaj yeem txhim kho cov yoj qeeb. Thib ob, nws yuav tshuaj xyuas qhov sib txuas ntawm cov nthwv dej qeeb thiab CSF ntws.

Ashok Litwin-Kumar, PhD, Pabcuam xibfwb, Lub Chaw Haujlwm ntawm Neuroscience thiab Lub Chaw Haujlwm Zuckerman, Columbia University, New York, NY

Connectome-Constrained Qauv ntawm Kev Coj Yoog Coj Tus Cwj Pwm

Hauv nws txoj kev tshawb nrhiav, Dr. Litwin-Kumar tsom qhia kev tsim qauv los coj lub ntiaj teb ntawm cov kev sib txuas (cov kab hlau txuas ntawm lub paj hlwb) thiab cov qauv kev coj tus cwj pwm ua ke los ntawm kev txhim kho txoj hauv kev txheeb xyuas cov kev teeb tsa uas muaj feem nyob rau hauv cov kev sib txuas uas tuaj yeem txwv tus qauv kev coj ua. - piv txwv li, los ntawm kev txwv cov qauv yog li lawv tsuas yog siv cov kev sib txuas sib txuas uas muaj lub cev sib txuas hauv lub cev, dua li kev ua kom lub cev tsis muaj peev xwm hla ntawm cov neurons.

Txhawm rau kuaj thiab ua kom zoo ntxiv ntawm cov txheej txheem no, Dr. Litwin-Kumar yog thawj qhov tsom mus rau txoj kev sib txuas ntawm ib feem ntawm cov txiv hmab txiv ntoo ya lub hlwb. Hauv ntu ntawm lub paj hlwb no, cov khoom siv nkag siab zoo tshaj tawm yog tsim tawm los ua cov neurons, uas ua rau coj tus cwj pwm xws li mus kom ze lossis zam kev tiv thaiv. Pab neeg yuav tshawb nrhiav yam ua kom tau txiaj ntsig zoo nyob rau ntawm qhov kev sib txuas uas qhia tau tias cov ntaub ntawv xov xwm huam tuaj li cas. Tom qab ntawv lawv yuav sim cov qauv kev kawm tob uas raug txwv los ntawm cov kev sib txuas ntawd kom pom tias lawv twv tau zoo npaum li cas rau cov lus teb rau stimuli, piv nrog cov qauv tsis ruaj khov.

David Schneider, PhD, Yaam Kws Tshawj, New York University, Chaw Rau Neural Science, New York, NY

Koosloos Hloov pauv hauv nas Cortex

Dr. Schneider kev ua haujlwm tsom rau kev tswj hwm lub cev muaj zog thiab hnov lub cheeb tsam ntawm lub paj hlwb ua haujlwm ua ke li no thiab yuav ua haujlwm los tshawb xyuas seb lub hlwb kawm paub li cas thiab tsim kev nco qab uas ua lub hauv paus ntawm qhov kev cia siab. Hauv nws qhov kev sim, Dr. Schneider tsom mus rau kev kho qhov sib txuas ntawm thaj chaw lub cev muaj zog mus rau thaj chaw hnov txog thaj chaw. Thaum twg los xij lub zog, ob thaj chaw sib txuas lus nyob rau hauv txoj hauv kev uas tau hais rau lub kaw lus tsis lees lub suab tsim los ntawm qhov kev txav ntawd.

Cov kev sim no yuav pab txheeb xyuas lub luag haujlwm ntawm cov neurons xav txog kev hnov cov lus hnov, qhov kev tswj lub cev muaj zog thiab lub chaw nruab ntug ntawm lub hlwb sib cuam tshuam li cas, thiab txoj kev ntawm thaj chaw ntawm lub cev muaj zog thiab qhov hloov pauv hloov thaum lub suab tshiab dhau los ua "kev cia siab." Cov kev tshawb nrhiav txuas ntxiv yuav thaiv qee txoj hauv kev hauv lub hlwb los txiav txim lawv lub luag haujlwm hauv kev twv ua ntej, thiab tseem pom tias lub hlwb siv cov kev tawm tswv yim pom zoo los pab nthuav tawm cov suab li cas.

Swathi Yadlapalli, PhD, Pabcuam xibfwb, Tsev Kawm Ntawv Kev Txhim Kho Tsev Kawm Qib Siab Michigan, Chav Haujlwm Cell thiab Kev Loj Hlob, Ann Arbor, MI

Cov Txheej Txheem Cellular Tswj Circadian Rhythms

Cov moos Circadian tsav ntau lub suab ntawm peb cov kab ke lom neeg, xws li thaum peb tsaug zog, sawv, peb metabolize, thiab ntau npaum li cas. Tab sis raws nraim qhov teeb meem tshwm sim nyob rau hauv ib qho ntawm tes muab los tsim cov lus sib dhos tsis tshua to taub. Cov kev tshawb nrhiav biochemical thiab keeb kwm yav dhau los tau txheeb pom cov protein tseem ceeb uas yog kev hloov pauv, txawm tias yog qhov zoo lossis kev txwv, muaj lub luag haujlwm hauv circadian rhythms. Dr. Yadlapalli tau tsim txoj hauv kev tshiab ntawm kev ua cov roj ntsha ntawm lub cev, lub siab pom tseeb ntawm cov roj ntsha no thiab lawv sib cuam tshuam li cas 24-teev hauv cov qe nyob ntawm cov txiv hmab txiv ntoo thawj zaug. Cov hau kev no tau hais txog lub luag haujlwm ntawm ib qho tseem ceeb ntawm qhov hloov pauv hloov chaw, hu ua PER, uas sib sau los ua foci tusyees faib ib ncig ntawm lub hnab ntawv ntawm lub xaim hluav taws xob, thiab ua lub luag haujlwm rau kev hloov chaw nuclear ntawm cov noob keeb thaum lub voj voog.

Hauv cov kev sim, Dr. Yadlapalli yuav txiav txim siab cov txheej txheem koom nrog hauv cov txheej txheem no - yuav ua li cas foci daim ntawv thiab qhov chaw lawv nyob hauv ib thaj chaw, thiab lawv yuav ua li cas los txhawb nqa kev tsuj ntawm cov noob-moos. Nkag siab ntxiv txog kev ua haujlwm ntawm cov hauv paus tseem ceeb no, muaj zog ntawm cov txheej txheem ntawm tes yuav muab kev pib rau kev tshawb fawb txog ntau txoj kev pw tsaug zog thiab lub cev thiab cov kab mob neurological.


Steven Flavell, Ph.D., Assistant Professor, Lub Tsev Kawm Ntawv Picower rau Kev Kawm thiab Kev nco, Massachusetts Lub Tsev Haujlwm Txuj Ci, Cambridge, MA

Kev Siv Lub Luag Tseem Ceeb Txheej Txheem Txiaj Ntsig ntawm Plab-Lub Hlwb Kev Txhim Kho hauv C. elegans

Me ntsis yog to taub txog yuav ua li cas lub plab thiab lub hlwb sib cuam tshuam mechanistically. Dr. Flavell qhov kev tshawb fawb yuav tsim ntawm kev nrhiav pom nws lub chaw kuaj mob tau ua rau kev kawm cov ntawv C. tej khaub ncaws cab, lawv cov leeg yooj yim thiab txhais tau zoo hauv lub paj hlwb tuaj yeem tsim cov kev coj tus cwj pwm uas yooj yim kawm hauv chav sim. Dr. Flavell thiab nws pab neeg tau txheeb xyuas qee yam tshwj xeeb ntawm cov leeg hlwb (lub hlwb txheej ntawm plab) uas tsuas yog lub cev C. tej khaub ncaws pub rau cov kab mob. Nws cov kev sim yuav txheeb xyuas cov kab mob cov kab mob uas ua kom cov neurons, soj ntsuam lub luag haujlwm ntawm lwm cov neurons hauv kev qhia txog plab, thiab tshawb xyuas seb cov lus tawm tswv yim los ntawm lub hlwb cuam tshuam qhov nrhiav tau ntawm tus kab mob plab. Qhov kev tshawb nrhiav no tuaj yeem qhib cov kab tshiab ntawm kev nug rau tib neeg cov kab mob me thiab seb nws cuam tshuam rau tib neeg kev noj qab haus huv thiab kab mob, suav nrog neurological thiab lub hlwb tsis zoo.

Nuo Li, Cov Ph.D., Assistant Assistant ntawm Neuroscience, Baylor College ntawm Tshuaj Kho Mob, Houston, TX

Cerebellar Cov Lus Sib Tham Thaum Lub Zog Tsav Tsheb

Dr. Li lub chaw kuaj mob tau qhia tias lub xub pwg sab xub ntiag lub cev cortex (ALM, ib qho tshwj xeeb ntawm cov nas ua ntej lub cortex) thiab cerebellum tau muab kaw rau hauv lub voj thaum lub sijhawm nas tau npaj rau kev nqis tes ua. Tseem tseem tsis tau paub meej tias cov ntaub ntawv dab tsi tau dhau mus thiab dhau los, tab sis nws txawv ntawm lub teeb liab uas ua rau cov leeg mob. Yog tias qhov kev sib txuas tau cuam tshuam txawm tias nyob rau lub sijhawm tam sim thaum lub phiaj xwm, qhov kev hloov yuav tau ua qhov tsis raug.

Dr. Li cov kev sim yuav nthuav qhia lub luag haujlwm ntawm cerebellum hauv kev npaj lub cev muaj zog thiab txhais cov qauv ntawm lub cev uas txuas nws thiab ALM. Nws yuav qhia txog cerebellar cortex thiab nrhiav seb cov neeg twg ntawm cov xov tooj tshwj xeeb uas siv hauv cerebellar suav, hu ua Purkinje cov hlwb, tau ua haujlwm los ntawm ALM hauv kev npaj lub cev muaj zog, thiab cov cim twg lawv xa rov qab thiab tawm thaum npaj. Qhov thib ob lub hom phiaj yuav tshawb xyuas seb cov kev sib koom tes ntawm cerebellum yog li cas. Los ntawm cov haujlwm no, Dr. Li yuav kawm paub ntau ntxiv txog cov txheej txheem ntawm lub hlwb.

Lauren O'Connell, Cov Ph.D., Assistant Assistant ntawm Biology, Stanford University, Stanford, CA

Neuronal Cov Hauv Paus Ntawm Niam Txiv Engrams hauv Cov Hlwb Hlawv Ntawm Menyuam

Dr. O'Connell kev ua haujlwm yuav pab txheeb xyuas qhov kev nco tau tsim li cas thaum tseem yog menyuam yaus ua ib feem ntawm cov txheej txheem sib khi, yuav taug qab cov cim xeeb sau ntawv kom paub tias lawv cuam tshuam txog kev txiav txim siab yav tom ntej, thiab yuav tshawb txog cov kev cuam tshuam ntawm lub paj hlwb ntawm kev cuam tshuam kev ua tiav. Hauv cov qav O'Connell tab tom kawm, tau txais zaub mov noj thiab kev saib xyuas coj tus tub luam mus rau niam txiv, uas cuam tshuam rau tadpole kev xaiv txij nkawm yav tom ntej: nws yuav nyiam cov phooj ywg uas zoo li tus neeg zov menyuam.

O'Connell tau pom cov cim neuronal uas tau nce siab rau cov tadpoles uas tau thov rau cov khoom noj uas zoo ib yam li cov kev cuam tshuam hauv cov kab mob neurological uas cuam tshuam txog kev kawm thiab kev coj tus cwj pwm hauv tib neeg. Nws cov kev tshawb fawb yuav tshawb txog neuronal architecture ua ke nrog kev paub txog menyuam mos thiab kev sib raug zoo nrog cov neeg saib xyuas, nrog rau lub hlwb kev ua haujlwm thaum txiav txim siab xaiv txij nkawm tom qab lub neej, saib seb neuronal cov haujlwm hauv txhua cov txheej txheem cuam tshuam li cas.

Zhaozhou Qiu, Cov Ph.D., Pabcuam xibfwb ntawm Physiology thiab Neuroscience, Johns Hopkins University, Baltimore, MD

Tshawb nrhiav Lub Cev Molecular thiab Kev Ua Haujlwm ntawm Cov Caj Dab Neeg Chloride Hauv Txheej Txheem

Ntau cov kev tshawb fawb txog niaj hnub tau tsom rau ntawm cov ion channel ua qhov zoo-ions, xws li sodium, potassium thiab calcium. Txawm li cas los xij, txoj haujlwm ntawm ion channels tso cai kom dhau ntawm chloride, cov feem ntau cuam tshuam tsis zoo-them ion, tseem tsis to taub. Los ntawm kev ua tiav ntawm qhov ntsuas ntawm genomics siab, Dr. Qiu thiab nws pawg neeg tshawb fawb tau txheeb xyuas ob tsev neeg tshiab ntawm chloride ua haujlwm, ua kom lub zog ntawm tes nce thiab pH acidic, feem. Nws cov kev tshawb fawb siv los tshuaj xyuas cov neurological ntawm cov kev tso cov ion tshiab nrog kev tsom mus rau kev sib cuam tshuam ntawm neuron-glia, synaptic plasticity, thiab kev kawm thiab nco. Dr. Qiu yuav txuas ntxiv txoj kev no mus rau lwm cov kev muaj cov tshuaj lom dawb hauv lub hlwb. Nws cov kev tshawb fawb yuav qhia qhov tseem ceeb rau kev yuav ua li cas cov tshuaj chloride raug tswj rau hauv cov hlab hlwb.

Maria Antonietta Tosches, Cov Ph.D., Pab xibfwb, Columbia University, New York, NY

Cov Evolution ntawm Gene Modules thiab Circuit Court motifs rau Cortical Inhibition

Niaj hnub nimno paj hlwb tau hloov los ntawm keeb kwm kev hloov pauv ntev. Dr. Tosches ua kev tshawb fawb kom nkag siab txog cov txheej txheem no thiab xam seb qhov twg neural systems tau khaws cia hauv cov tsiaj txha caj qaum tau cais los ntawm ntau pua pua xyoo ntawm kev hloov zuj zus.

Dr. Tosches tshawb txog keeb kwm kev hloov pauv ntawm GABAergic neurons. Nws cov kev sim yav dhau los tau pom GABAergic neurons ntawm cov tsiaj reptiles thiab cov tsiaj lub cev muaj qhov zoo sib xws, qhia tias cov neuron no muaj nyob rau hauv cov keeb kwm yav dhau los pog koob yawg koob; lawv kuj qhia cov qauv txuas nrog cov kev ua haujlwm neuronal tshwj xeeb hauv ob hom paj hlwb. Hauv Tosches 'kev tshawb nrhiav tshiab, nws yuav txiav txim siab yog tias cov neurons zoo tib yam no pom hauv cov hlwb yooj yim ntawm salamanders. Qhov kev ua haujlwm no yuav qhia txog tus qauv tshiab tsiaj txhu txuas rau lub hlwb hluav taws xob, ntxiv rau peb txoj kev nkag siab txog seb lub hlwb ua haujlwm npaum li cas.

Daniel Wacker, Cov Ph.D., Yaam Kws Tshawj, Icahn Tsev Kawm Ntawv ntawm Cov Tshuaj ntawm Mount Sinai, New York, NY

Kev Tshawb Nrhiav Kev Kub Ntseg rau cov tshuaj pom rau qhov tsis meej ntawm kev paub los ntawm kev teeb tsa kev tshawb fawb ntawm Serotonin Tus Txais

Dr. Wacker tawm tswv yim tshiab txog kev nrhiav cov tshuaj uas tsom mus rau ib qho tshwj xeeb serotonin receptor hu ua 5-HT7R (uas tsis muaj kev pheej hmoo tib yam li kev ua kom lub cev dopamine ntau li cov tshuaj ua), ua zoo taw qhia tias cov txheej txheem receptor ntawm cov qauv molecular, thiab nrhiav cov tebchaw uas yuav khi rau qhov receptor hauv txoj kev tshwj xeeb. Dr. Wacker tawm tswv yim los ua qauv kev tshawb fawb ntawm tus tsim kom siv cov duab xoo hluav taws xob ntawm cov duab xoo hluav taws xob rau kev ua kom huv ntawm cov receptor. Wacker pab pawg yuav ua qhov kev tshawb fawb hauv koos pis tawj ntawm ntau pua lab ntawm kev sib txuas, piv lawv 3D qauv nrog cov qauv 3D ntawm lub receptor rau cov uas yuav "haum." Cov txheej txheem khoos phis tawm no muaj txoj hauv kev zoo rau kev tshuaj xyuas ua ntej raws li lawv cov qauv, thiab ua kom lawv txoj kev loj hlob sai.


Jayeeta Basu, Ph.D.Pab xibfwb, Neuroscience Institute, New York University School of Medicine, New York, NY

Cortical Sensory Modulation ntawm Hippocampal Kev Ua Si thiab Spatial Sawv Cev

Basu aims rau daim ntawv qhia lub circuitry kev koom tes ntawm cov LEC thiab ib qho hippocampal neurons. Nws lub chaw kuaj yuav ncaj qha rau cov ntawv cim tseg uas tau txais los ntawm cov dendrites ntawm cov neurons thaum LEC cov teebmeem xa nrog lossis tsis muaj MEC cov cim, thiab ntawm cov teeb liab txawv. Lub sijhawm thib ob ntawm kev sim nrog cov nas yuav kuaj qhov pom tau tias cov LEC nkag los txhawb qhov kev tsim ntawm qhov chaw ntawm qhov chaw thaum kawm - ntxhiab cues yuav ua rau tus cwj pwm kom nrhiav kev ntshaw ntawm cov chaw. Cov neeg tshawb xyuas yuav pom tias yuav pib los sis tawm LEC cov teeb tseg thaum kawm ntawv lossis thaum lub sijhawm rov ua haujlwm tuaj yeem cuam tshuam rau qhov chaw ntawm lub hlwb hauv hlwb thiab kev coj tus cwj pwm nws tus kheej. Kev tshawb nrhiav no tej zaum yuav tseem ceeb rau yav tom ntej ntawm Alzheimer's disease, PTSD thiab lwm yam kev mob uas muaj qhov cim xeeb thiab cov ntsiab lus "ua rau" ua haujlwm.

Juan Du, Ph.D., Kws Tshaj Lij Cov Thawj Coj, Qhov Kev Pabcuam Tej Dej Num, Lub Chaw rau Kev Mob Nkeeg thiab Lub Cev Rau Lub Cev, Lub Ntiaj Teb Kev Loj Thiab Cov Kev Tshawb Fawb Van, Grand Rapids, MI

Kev cai tswj ntawm thermosensitive receptors nyob rau hauv lub hlwb

Dr. Du yuav coj peb txoj haujlwm rau kev qhib lub secrets ntawm qhov kub thiab txias ntawm cov ntaub ntawv tau txais thiab kev ua haujlwm los ntawm cov neural system. Nws saib peb cov neeg txais kev pom zoo, ib qho uas pom txias thiab txias txias sab nraud, ib qho uas ua rau sab nraud sab nraud, thiab ib qho uas pom sov sov nyob hauv lub hlwb (rau kev tswj lub cev kub.) Nws yuav xub xub nrhiav cov neeg ua haujlwm kom zoo lawv muaj peev xwm muab rho tawm thiab siv hauv kev sim (lab) thiab tseem ua haujlwm ib yam li cov neeg nyob hauv lub cev.

Ib qho laj thawj thib ob yog pom dab tsi ntawm cov neeg tau txais kev pab cuam los ntawm qhov ntsuas kub thiab to taub tias lawv ua haujlwm li cas. Qhov no kuj yuav muaj kev tsim kho cov kev kho tshiab uas yuav khi rau cov qauv no thiab tswj lawv. Thib peb, thaum twg cov teeb meem tau to taub, kev sim kev ua haujlwm uas cov neeg txais kev hloov pauv yuav hloov los yog tshem tawm cov kev kub ntxhov siab, thawj zaug ntawm cov hlwb, thiab tom qab ntawd hauv nas, pom qhov hloov qhov kub thiab txias li cas.

Mark Harnett, Ph.D.Pab xibfwb, Lub hlwb thiab kev paub qab hauMassachusetts Lub Tsev Kawm Txuj Ci, Cambridge, MA

Perturbing Dendritic Compartmentalization los soj ntsuam Ib Neuron Cortical Computations

Dr. Harnett saib cov dendrites hauv qhov muag pom nrog cov cuab yeej hluav taws xob thiab cov cuab yeej siv kho qhov muag, ntsuas seb qhov teeb meem khiav mus rau hauv cov ceg ntoo, thiab ntsuas qhov kev hloov kho qhov kev hloov li cas rau lub paj hlwb. Cov perturbations no yuav cia tus Dr. Harnett sim seb puas muaj kev cuam tshuam rau ntawm ib qho kev hloov ntawm cov kev hloov dendrite li cas neural network ua rau qee qhov muag pom. Kev kawm hais tias ib qho neuron yog qhov tseem ceeb ntawm nws tus kheej lub network ntawm cov teeb meem me me yuav hloov peb nkag siab txog qhov ua li cas lub paj hlwb siv nyiaj. Ntawm lwm yam, qhov no yuav cuam tshuam li cas artificial txawj ntse, uas yog tus qauv ntawm cov neural network, evolves hauv xyoo tuaj.

Weizhe Hong, Ph.D.Pab xibfwb, Saibxyuas ntawm Chemistry Biology thiab Neurobiology, University of California, Los Angeles, CA

Neural Circuit Mechanisms ntawm Maternal Behaviour

Ib qho tseem ceeb ntawm Dr. Hong txoj haujlwm yuav los tshuaj txog lub luag haujlwm ntawm kev tiv thaiv hlwb hauv cheeb tsam hu ua amygdala los tswj kev coj tus cwj pwm. Cov poj niam nas feem ntau ua rau cov tub ntxhais kawm coj cwj pwm zoo, cov txiv neej feem ntau tsis coj tus cwj pwm li niam txiv kom txog thaum lawv cov me nyuam yug los.

Cov kev tshawb fawb yuav taw qhia tshwj xeeb, molecularly txhais cov neuronal coob leej uas tuaj yeem ua tus coj tus cwj pwm. Cov kev tshawb fawb tseem yuav piv cov paj hlwb hauv cov txiv neej thiab cov poj niam kom to taub tias kev ua neural hauv cov neurons no tswj kev coj tus cwj pwm li cas. Cov kev tshawb fawb no yuav muab cov ntsiab lus tseem ceeb rau hauv lub hauv paus ntawm ib qho tseem ceeb ntawm kev coj tus cwj pwm thiab cov cai ntsiab lus tswj kev coj tus cwj pwm txawv ntawm kev sib daj sib deev.

Rachel Roberts-Galbraith, Ph.D.Pab xibfwb, Department of Cellular Biology, University of Georgia, Athens, GA

Rov ua dua ntawm Lub Hauv Paus Xeeb Tub Rog hauv Planarians

Los ntawm kev kawm txog kev ua haujlwm zoo hauv lub ntiaj teb ntuj, Dr. Roberts-Galbraith cia siab kawm txog cov tswv yim txog kev tsim kho kev sib daj sib deev thiab lub luag haujlwm ntawm ntau lub hlwb. Ib lub hom phiaj yog tshawb xyuas seb cov neurons puas tuaj yeem pom kev raug mob thiab kho lawv tus kheej kho lawv tus kheej los ntawm kev xa tawm cov teebmeem uas tsim thiab tswj qis rau regrowth. Dr. Roberts-Galbraith pom tias cov kab mob neurons tau hloov cov qog hlwb qia hlwb, uas tau nrhiav kom tau qee qhov ntawm lub hauv nruab nrab ntawm lub paj hlwb (thiab lwm yam ntawm lub cev). Kev tswj zoo ntawm cov qia hlwb yog qhov tseemceeb rau kev tsim kho tshiab, vim tias cov neeg tsis paub qab hau zoo li hloov cov ntaub so ntswg uas ploj lawm thiab tsis tsim cov qog.

Lwm lub hom phiaj yog mus xyuas lub luag haujlwm ntawm glial hlwb, uas tau kev lig kev cai tau pom raws li lub kua nplaum ntawm lub paj hlwb, tab sis cov uas pom meej muaj ntau yam tseem ceeb dua li yav tas los pom. Glial hlwb ua ib feem ntawm cov tsiaj txhu 'lub paj hlwb thiab yuav tsum tau rov tsim nrog cov neurons; lawv kuj yuav tsim kho cov dej neuronal. Qhov kev cia siab yog qhov kev tshawb fawb no yuav ua rau kom nkag siab txog qhov kev tsim kho tshiab li cas rau cov neeg tau zoo tshaj plaws, thiab tej zaum qhia txog txoj kev tshiab ntawm kev xav txog kev ua rau cov neeg tsis muaj hlwb.

Shigeki Watanabe, Ph.D.Pab xibfwb ntawm Cell Biology thiab Neuroscience, Johns Hopkins University, Baltimore, MD

Mechanistic Insights rau hauv Membrane hloov tawm ntawm Synapses

Watanabe yuav siv cov txheej txheem hu ua flash-and-freeze electron microscopy los tshawb nrhiav cov txheej txheem no. Neurons yuav tsim nrog lub teeb - lub flash - ces txoj kev yuav tsum nres precisely nrog high-pressure freezing ntawm lub sij hawm kom ncaj lub sij hawm microseconds tom qab stimulation. Cov khov nab kuab tom qab tau ua rau pom kev nrog lub tshuab hluav taws xob. Los ntawm kev noj cov dluab ntawm khov kho ntawm cov sij hawm sib txawv ntawm lub sijhawm ua kom tiav, Dr. Watanabe yuav tsim ib txoj kev los ua ke ntawm cov txheej txheem thiab txheeb xyuas cov proteins uas koom nrog thiab lawv ua li cas. Tsis yog qhov no tsuas yog qhov kev nkag siab zoo txog kev siv cov neurons ua haujlwm xwb, nws muaj qhov cuam tshuam rau cov kabmob uas muaj feem xyuam rau qhov ua tsis zoo rau lub hlwb, xws li Alzheimer's Disease.


Eiman Azim, Ph.D., Pab xibfwb, Molecular Neurobiology Laboratory,

Salk lub koom haum rau kev tshawb fawb txog Biological, La Jolla, CA

Sab Nraud Cov Hluav Taws Xob Kev Tswj Dexterous Forelimb Movement

Kev coj ntawm peb sab caj npab, txhais tes thiab ntiv tes yog qhov tseem ceeb rau peb txhua hnub kev sib tham nrog lub ntiaj teb, tiam sis science yog pib nqus qhov kev nkag siab tias kev tswj xyuas neural zoo li cas tswj qhov kev txiav txim, kev ceev thiab kev ncaj ncees ntawm cov kev coj cwj pwm zoo no. Dr. Azim txoj kev sim ntawm Salk Lub Tsev Haujlwm yog nyob rau ntawm thawj hom kab ke no, tabtom npaj txoj kev sib txig sib luag rau kev tawm tsam cov qauv molecular, anatomical thiab lub cev muaj zog ntawm txoj kev ua haujlwm ntawm ib txoj hauv kev ib zaug. Ua kom zoo dua rau cov kev kawm tshuab raj, kev siv tshuab computer pom thiab cov cuab yeej cuab tam cov cuab yeej, Azim Lub Hom Phiaj xav tsim ntau tus qauv zoo, kev kawm tsis sib haum, kev sib txeeb, kev sib koom tes ua ke nrog kev sib koom ua ke - thiab hlob. Nws cov kev tshawb pom yuav pab qhia tau hais tias kev kis kab mob los yog kev puas tsuaj cuam tshuam li cas ntawm kev ua haujlwm ntawm kev khiav dej num, paving txoj kev rau kev txhim kho mob thiab kev kho mob.

Rudy Behnia, Ph.D., Pab xibfwb ntawm Neuroscience, Columbia University-Zuckerman Ntse hlwb paj hlwb lub koom haum, New York, NY

Lub State-dependent Neuromodulation ntawm Circuit for Motion Vision

Dr. Behnia tau tshawb cov txheej txheem ntawm kev ua kom qhov muag pom, kev tshawb kawm txog lub hlwb qhov muag pom kev coj tus cwj pwm thiab pab tsiaj thiab tib neeg ciaj sia thiab muaj peev xwm nyob rau hauv cov cheeb tsam nyuaj teem nrog kev hnov suab paj nruas. Kev siv cov txiv hmab txiv ntoo lub cev ua qauv, Behnia tus kuaj tshawb xyuas saib tsiaj txhu li cas thiab hloov lawv tus cwj pwm mus rau kev hloov pauv ntawm ntau hom kev sib txuas ua ke, nrog rau nyob rau hauv vivo ib qho cell cell-clamp recordings, ob-photon kev ua-duab, optogenetic thiab tus cwj pwm coj cwj pwm. Ib qho tseem ceeb ntawm Dr. Behnia McKnight nyiaj txiag ua haujlwm yuav tsum tshawb pom li cas hauv lub xeev xws li kev saib xyuas hloov lub hlwb cov kev xav txog tej stimuli, kev tshawb fawb uas yuav tso tau lub teeb tshiab rau ntawm lub luag hauj lwm neuromodulators ua si hauv kev hloov cov kev ua ntawm cov neural circuits. Cov kev tshawb fawb no tseem tuaj yeem qhia cov hom phiaj tshiab rau cov tswv yim kho mob xws li kev nyuaj siab thiab ADHD.

Felice Dunn, Ph.D., Lwm tus xibfwb qhia txog Ophthalmology, University of California, San Francisco

Lub Koom Haum thiab Kev Cai Tswj ntawm Qws thiab Lub Hlwb Lub Zeem Muag

Dr. Dunn cov kev tshawb fawb tau npaj rau kev tshawb pom cov ntaub ntawv li cas thiaj parsed thiab tiav hauv qhov retina Circuit Court, kev paub uas yuav qhib tau txoj hauv kev tshiab rau kev kho qhov muag tsis pom kev. Thaum muaj ntau yam kab mob plab uas ua rau tsis pom kev los sis dig muag pib nrog qhov degeneration ntawm photoreceptors, seb tus kab mob mus rau qhov teeb meem mus rau cov postsynaptic neurons yog qhov tseem tsis tau paub. Hauv nws txoj kev kuaj pom, Dunn muab cov kev hloov ntawm cov neeg siv photoreceptors, cov ntaub ntawv xov xwm thiab kev pom ntawm cov qe hlwb, thiab cov txheej txheem kev tshawb nrhiav txog kev tshawb nrhiav cov retina hauv hlwb thiab synapses. Nws txoj haujlwm yuav pab kom paub tias lub vev xaib ntxiv nws cov qauv thiab kev ua haujlwm hauv lub degenerating retina, thiab yuav pab qhia tau cov kev kho mob rau kev txwv los tiv thaiv kev tsis pom kev.

John Tuthill, Ph.D., Pab xibfwb, Physiology thiab Biophysics, University of Washington, Seattle

Kev Siv Tswv Yim Tswj Haujlwm Saib Xyuas Kev Nyuaj Siab nyob ntawm Drosophila

Kev tsim nyog-lub cev kev xav ntawm tus kheej lub zog thiab txoj hauj lwm-yog qhov tseem ceeb, rau txoj kev tswj hwm ntawm kev txav, tseem tsis tshua paub txog tias lub hlwb lub cav sib txuas cov tswv yim no los coj cov kev taw qhia yav tom ntej. Dr. Tuthill's lab yog ua haujlwm kom qhib lub hauv paus ntawm txoj kev kawm hauv lub hlwb los ntawm kev tshawb nrhiav cov paj txiv hmab txiv ntoo tuaj yeem kawm kom tsis txhob muaj teeb meem thiab taug txoj kev tsis tuaj yeem ua qhov chaw, kev txheeb xyuas lub luag haujlwm ntawm cov kev tawm tswv yim hauv kev tsav tsheb los ntawm optogenetically manipulating proprioceptor activities. Qhov kev nkag siab tob zog ntawm kev tawm tswv yim tswj proprioceptive muaj peev xwm los hloov txoj hauv kev uas peb to taub thiab kho cov kev mob ntawm cov tsiv.

Mingshan Xue, Ph.D., Pab xibfwb, Baylor College of Medicine, Houston, TX

Kev muaj nuj nqi thiab Mechanism ntawm lub tswv yim-specific Homeostatic Synaptic yas nyob rau hauv Vivo

Txhawb txoj kev sib luag thiab hloov hauv lub xeev, lub hlwb noj qab nyob zoo tswj qhov kev sib npaug ntawm qhov kev sib tw thiab kev tiv thaiv (feem ntau yog qhov sib piv li E / I piv) uas yog qhov chaw ruaj khov. Npaum li cas lub hlwb tswj kom qhov nyiaj no? Dr. Xue's laboratory yuav tshawb txog lo lus nug no, muab cov ntsiab lus ntawm cov tshuaj molecular, genetic, electrophysiology, optogenetic, kev ntsuam xyuas, thiab kev sib raug zoo ntawm lub hauv paus los txiav txim siab seb qhov homeostatic yas tswj cov synapses hauv ib qho kev tawm tswv yim zoo hauv vivo, ua li cas tswj cov qib siab neuronal thiab cov lus teb. Nkag mus rau qhov tob tob kom paub meej tias lub hlwb lub hlwb zoo licas nrog kev ua rau perturbations muaj peev xwm ua rau txoj kev pabcuam los kho cov kab mob hauv lub hlwb uas cuam tshuam rau lub hlwb lub ntuj tshuav.

Brad Zuchero, Ph.D., Pab xibfwb ntawm Neurosurgery, Stanford University, Palo Alto, CA

Mechanisms ntawm Myelin Membrane Loj Hlob thiab Hloov

Qhov poob ntawm myelin-roj hluav taws xob insulator nyob ib ncig ntawm neuronal axons-yuav ua rau lub cev muaj zog loj thiab lub hlwb khiav tsis zoo hauv cov neeg mob uas muaj ntau yam sclerosis thiab lwm yam kab mob ntawm lub hauv nruab nrab lub paj hlwb. Ua ib lub "textbook model" ntawm cov qauv mechanism uas tsav myelin tsim yog tam sim no lub hom phiaj ntawm Dr. Zuchero txoj kev tshawb nrhiav nyob hauv Stanford University. Kev sib txuas lus nrog rau kev sib tw nrog CRISPR / Cas, thiab cov cuab yeej tshiab hauv kev tsim kho cov cuab yeej tshiab, thiab Zuchero cov pab pawg yuav tshawb xyuas seb yog vim li cas thiab vim li cas cov paj hlwb yuav tsum muaj kev cuam tshuam cov kev ua haujlwm ntawm cov oligodendrocyte actin cytoskelton, qhia lub hom phiaj tshiab los yog kev kho mob rau kev kho tshiab thiab kho kho.


Martha Bagnall, Ph.D., Pab xibfwb ntawm Neuroscience, Washington University hauv St. Louis Lub Tsev Kawm Ntawv ntawm Tshuaj

Xuas tes taw thiab lub laij lej pib ntawm kev tswj cov teebmeem 

Kev tshawb no yog ib qho tseem ceeb rau kev ua haujlwm zoo, tab sis me ntsis yog paub txog tias lub hlwb ua tau zoo licas txog kev taw qhia, kev txav mus los ntawm lub caj dab qaum kom lub cev "sab sab." Dr. Bagnall kev tshawb fawb txog cov tsiaj nyob rau hauv vestibular system ntawm lub zebrafish, ib tug qauv kab mob nrog ib tug spinal qaum remarkably zoo li limbed mammals. Hauv kev loj hlob thaum ntxov, tus txha caj qaum ntawm larval zebrafish yog pob tshab, muab cov neeg tshawb nrhiav pom zoo rau ntau haiv neeg ntawm cov neurons pib thaum muaj ntau hom kev taw. Los ntawm kev kawm ntau ntxiv txog qhov cov kev sib txawv ntawm cov khoom ua ntej no yuav raug rau thaum lub sijhawm tus cwj pwm txawv-uas pub tsiaj txhim kho cov kev hloov hauv txoj kab thiab kev sib tw-Bagnall qhov kev tshawb fawb muaj peev xwm qhia tshiab discoveries txog kev sib sib zog neural sib txuas uas tswj kev coj tus cwj pwm ntawm tib neeg. Nws txoj haujlwm kuj qhia tau rau cov kev pabcuam uas tuaj yeem pab neeg kom rov tau lawv cov nyiaj seem thiab ua kom tau zoo, thiab txhim kho cov neeg lub neej uas tsis muaj kev raug mob los ntawm kev raug mob los yog kab mob.

Stephen Brohawn, Ph.D., Pab xibfwb txog Neurobiology, Helen Wills Neuroscience Lub Tsev Kawm Ntawv, University of California, Berkeley

Mechanisms ntawm biological quab yuam sensation

Dr. Brohawn tau kawm txog lub neej txoj kev khiav hluav taws xob los ntawm ib qho kev xav ntawm lub cev thiab biophysical, nrog rau txoj kev nrhiav cov lus teb rau lo lus nug "Peb xav li cas? "  Lub paj hlwb muaj peev xwm paub cov neeg dag zog yuam yog ib qho ntawm cov ntsiab lus ntawm lub rooj sib hais thiab kev sib npaug, tab sis kev tshawb fawb tseem tsis tau qhia cov tshuab protein uas hloov cov khoom siv dag zog rau hluav taws xob teeb liab. Siv cov lej ntawm xoo hluav taws xob (crystallography) rau cryo-electron microscopy, Brohawn's (lab) yuav siv cov lus nug, ntes atomic kev daws teeb meem ntawm cov kua membrane thaum lub sij hawm so thiab nyob hauv lub zog. Mus nkag siab txog kev hnov lus thiab kev tshuav nyiaj li cas hauv ib theem ntawm cov ntsiab lus muaj peev xwm ua rau muaj ib lub hauv paus rau cov kev kho tshiab los txhim kho lub neej ntawm cov neeg uas tau txais kev hnov lossis kev ua haujlwm tsis muaj nuj nqi.

Mehrdad Jazayeri, Ph.D., Pab xibfwb, Massachusetts Lub koomhaum Technology / McGovern Lub Tsev Kawm Ntawv Lub Cev Kev Ntshav

Thalocortic mechanisms ntawm cov sijhawm ua haujlwm ywj pheej

Dr. Jazayeri kawm txog tias lub paj hlwb ua zoo npaum li cas los ntawm kev tshawb nrhiav lub hlwb lub hlwb kom peb cia siab rau, ntsuas, thiab muab me ntsis sij hawm ua ke. Los ntawm kev sib tham, kev kawm suab paj nruag, kev ua si, kev ua si yuav tsum yog qhov tseem ceeb ntawm kev paub thiab kev ua haujlwm, tiam sis cov ntsiab lus ntawm qhov pib thiab cov txheej txheem ntawm lub sijhawm tseem tsis paub. Yuav kom tshawb txog qhov tseem ceeb ntawm cov vaj tse uas cognition, Jazayeri qhia cov neeg ua haujlwm rau kev tsim tawm lub sijhawm, xws li kev ua kom ntaus suab paj nruag - nws yog ib qho tseem ceeb ntxiv raws li nws txoj kev tshawb fawb ua hauj lwm kom paub txog lub hlwb lub hauv paus ntawm kev sib nkag siab txog kev nkag siab, qhov tseem ceeb ntawm kev sib tham thiab kev muaj lub peev xwm. Nws txoj kev tshawb fawb yuav ua rau peb nkag siab txog qhov yooj yim ntawm kev ua kom peb pom zoo, hloov cov lus qhia tshiab, thiab txiav txim siab, thaum paub cov hom phiaj loj rau ntau yam kev paub txog.

Katherine Nagel, Ph.D., Pab xibfwb, Tsev Kawm Tshiab New York University School of Medicine / Neuroscience Institute

Neural mechanisms pib qhov kev tshawb fawb nrhiav kev coj cwj pwm hauv drosophila melanogaster

Dr. Nagel tau tshawb pom cov kua txiv hmab txiv ntoo sib txuas ua ke li cas rau lawv cov khoom noj - kev coj cwj pwm yooj yim uas yuav ua rau lub teeb ci tshiab rau hauv lub paj hlwb uas ua rau lub hlwb tig tig los ua. Tus qauv kabmob uas muaj lub hlwb yooj yooj yim thiab muaj peev xwm ua kom "kev txiav txim siab ntawm lub tis," cov txiv hmab txiv ntoo yoov tshoob thaum lawv ntsib cov ntxhiab tsw ntawm ib qho txaus nyiam, thiab nrhiav downwind thaum ntxhiab poob. Yuav nrhiav cov khoom noj khoom haus, cov yoov yuav tsum muab cov khoom siv, cov khoom siv, thiab cov khoom siv coj los ua ke, thiab hloov cov khoom siv no kom muaj txiaj ntsig zoo. Nagel's siv cov kev ntsuam xyuas tus cwj pwm coj, kev siv lub dag zog, kev ua rau caj ces, thiab kev ua kom paub tias qhov kev cuam tshuam no ua haujlwm li cas ntawm tib lub cell level, muab teeb ci rau ib qho ntawm lub hlwb cov kev cob qhia tshaj plaws. Nagel txoj kev tshawb fawb muaj peev xwm ua rau cov kev qhia tshiab, qhia tawm ntxiv txog seb lub hlwb zoo li cas hauv chaw thiab sij hawm, los pab qhia txog kev loj hlob ntawm lub cev robots.

Matthew Pecot, Ph.D., Lwm tus xibfwb, Harvard Medical School

Txhais cov lus tseeb ntawm cov keeb kwm neural network sib txuas hauv Drosophila qhov muag pom 

Qhov kev txiav txim uas cov kev sib txuas ntawm cov neurons hauv kev sib txuas sib txuas yog qhov tseem ceeb rau kev coj tus cwj pwm, tsis li cas neurons txheeb xyuas cov neeg koom nrog cov synaptic thaum nyob hauv lub qhov tsis yooj yim ntawm cov hlab hlwb tsis meej. Los txheeb xyuas cov qauv hauv cov qauv ntawm cov qauv hauv Pecot cov kev tshawb fawb txog neural txuas hauv cov yoov qhov muag pom tau, uas muaj cov ntsiab lus zoo heev uas siv tau cov kab mob neuron zoo nrog cov qauv paub ntawm synaptic connectivity. Raws li lawv cov kev tshawb fawb, lawv tshaj tawm tias cov neeg sib koom nrog cov neeg sib koom tes yog ib qho kev nthuav qhia tus kws tswj tus cwj pwm (protein) uas tswj cov kev qhia txog cov molecules uas qhia lawv cov kev sib txuas ntawm synaptic. Xyuas kom paub tias cov neurons tau muab rau cov kev sib txuas qhia tau hais tias tus thawj tswj hwm tus thawj tswj tsev kawm ntawv yuav muab tau ib qho tswv yim yooj yim rau kev tsim cov kev sib txuas neural ncaj. Nrog rau lub cev loj ntawm cov pov thawj paub cov teeb meem hauv neural txuas mus ua ib tug neeg tsav tsheb nyob hauv tus kab mob neurological, Dr. Pecot txoj kev tshawb fawb yuav txhawb kev kho cov tswv yim tsom rau rewiring puas tsuaj neural circuits nyob rau hauv cov tib neeg.

Michael Yartsev, Ph.D., Bioengineering Assistant Professor, Helen Wills Neuroscience Lub Tsev Kawm Ntawv, University of California, Berkeley

Neurobiological yog lub hauv paus ntawm kev kawm suab paj nruag nyob rau hauv lub paj hlwb loj hlob hlwb

Lus dag ntawm lub plawv ntawm nws txhais tau tias yog tib neeg. Peb muaj lub peev xim rau txoj kev kawm suab uas peb qhia nrog rau ntau hom tsiaj txhu. Dr. Yartsev pib ua qhov kev tshawb nrhiav thawj zaug ntawm lub suab paj nruag lub hlwb, siv cov txiv hmab txiv ntoo Miv txiv hmab txiv ntoo los pab teb cov lus nug txog seb nws yog hais txog peb lub hlwb uas tso cai rau peb kawm lus. Siv cov kev yees duab tshiab li cov ntaub ntawv teev cov xov tooj cua tsis zoo, optogenetics, kev ntsuam xyuas thiab kev tshawb fawb tsom iav, Yartsev thiab pab neeg no kom cia siab rau cov tswv yim neural uas ua rau lub hlwb muaj peev xwm tau txais cov lus. Yartsev txoj haujlwm kuj tuaj yeem ua rau cov lus tshiab rau hauv kev hais lus me me, kev ntseeg, thiab lwm yam lus thiab kev puas hlwb.


Mark Andermann, Ph.D., Pab xibfwb ntawm tshuaj, Beth Israel Deaconess Medical Center, Harvard Kho Mob Tsev Kawm Ntawv

Ib txoj hauv kev rau kev hloov kev tshaib plab ntawm cov khoom noj khoom haus cue cov lus teb hauv kab cortex

Dr. Andermann txoj kev tshawb fawb hais txog lub hlwb lub hlwb pom thiab ua raws li cov duab txog zaub mov, tshwj xeeb tshaj yog thaum tus neeg tshaib plab. Nws txoj haujlwm yog tsav los ntawm lub zej zog neeg xav tau los tsim cov kev qhia dav rau kev rog. Tib neeg to taub cov khoom uas lawv lub cev qhia rau lawv tias lawv xav tau. Tshaj tawm rau cov khoom noj khoom haus cues, uas ua rau nrhiav khoom noj ntau tshaj qhov tsim nyog tau, tuaj yeem mob siab rau cov neeg muaj mob los ntawm kev rog los yog kev noj zaub mov mob, txawm tias thaum lub sij hawm. Andermann's lab tau tsim ib txoj kev uas muaj ob-photon calcium uas yog siv los ntawm ib tug periscope los kawm txog pua pua neurons hauv nas lub hlwb, thiab pom tias lub hlwb cov lus teb rau cov zaub mov muaj feem xyuam nrog cov zaub mov txawv nyob ntawm seb tus nas tau tshaib plab los yog hais txog dab tsi. Lub npe Andermann tau koom tes nrog Dr. Brad Lowell lub chaw kuaj ntshav hauv lub hlwb hauv kev tswj hwm kev tshaib kev nqhis-kawm txog cov kab cortex hauv kev tshawb nrhiav txog kev tiv thaiv cov khoom noj tsis zoo rau cov khoom noj tsis zoo.

John Cunningham, Ph.D., Pab xibfwb, Department of Statistics, Columbia University

Tus qauv ntawm cov pej xeem ntawm cov neurons hauv lub cev cortex

Dr Cunningham txoj kev tshawb fawb ntawm lub hom phiaj yog los ua kom paub qhov kev nkag siab ntawm lub hlwb ntawm cov yeeb yam dav. Piv txwv, zoo dua kev nkag siab txog lub hlwb lub luag haujlwm hauv kev tsim kom muaj kev ywj pheej ywj pheej muaj peev xwm pab tau tsheej lab ntawm cov neeg uas muaj kev xiam oob khab vim raug mob thiab raug mob. Cunningham yog ib feem me me tiam sis loj hlob ntawm cov kws tshawb fawb siv cov ntaub ntawv thiab tshuab kev kawm txog kev tshawb fawb txog neuroscience. Nws muab ntau hom kev ua lej, txheeb cais, thiab kev siv computer los tshem tawm cov ntsiab lus muaj txiaj ntsim los ntawm datasets loj heev hauv cov kev sim. Nws lub hom phiaj yog kom muaj qhov sib txawv ntawm cov ntaub ntawv teev cov ntaub ntawv thiab cov nyiaj them nuj nqi, nrhiav kev tsim cov cuab yeej analytical nws thiab lwm cov neeg tshawb xyuas ua ke. Kev sojntsuam kev muaj peevxwm ntawm kev siv cov datasets loj heev yog qhov tseem ceeb rau kev ua haujlwm, tshwj xeeb yog cov kws soj ntsuam cov ntaub ntawv txhua hnub ntawm kev ua kom tsis muaj teeb meem.

Roozbeh Kiani, MD, Ph.D., Pab xibfwb, Tsev Kawm Ntawv New York, Center for Neural Science

Hierarchical kev txiav txim siab uas khiav lag luam dua lub sij hawm teev kom zoo tshaj qhov kev xaiv thiab cov kev hloov hauv cov tswv yim

Dr. Kiani yog tshawb fawb txog kev coj tus cwj pwm coj li cas thaum txiav txim siab. Kev txiav txim siab yog qhia los ntawm cov ntaub ntawv thiab cov tswv yim txuas rau kev nqis tes ua. Ua raws li qhov tsis zoo, ob lub tswv yim ntawm kev yuam kev tsis zoo thiab cov lus qhia tsis zoo-yuav tsum yog qhov txawv kom zoo ntxiv yav tom ntej. Cov txheej txheem no yog nyob ntawm kev cuam tshuam ntawm ntau lub tsev qiv ntawv thiab cov chaw qiv hauv qab sib koom ua ke uas sawv cev ncaj ncees cov ntaub ntawv, rov qab nrhiav kev xav, thiab npaj thiab ua raws li cov kev xav ua. Kiani cov kev tshawb fawb tsom rua cov txheej txheem neuronal uas ua raws li cov txheej txheem no, tshwj xeeb tshaj yog cov ntaub ntawv cov ntaub ntawv tau muab los sib qhia, cov ntaub ntawv xaiv tau raug xaiv thiab khiav tau yooj yim ntawm ib cheeb tsam ntawm lub hlwb mus rau lwm qhov, thiab seb qhov kev txiav txim siab ua rau sawv kev ntseeg cov txiaj ntsim tau tshwm sim. Nws txoj kev tshawb fawb muaj feem cuam tshuam rau kev kawm txog cov kev puas hlwb (neurological disorders) uas cuam tshuam kev txiav txim siab xws li schizophrenia, obsessive-compulsive disorder, thiab Alzheimer's.

Yuki Oka, Ph.D., Pab xibfwb ntawm Biology, California Lub Tsev Kawm Ntawv ntawm Kev Siv Tshuab

Peripheral thiab Central Mechanisms ntawm lub cev dej tswj

Dr. Oka txoj kev tshawb fawb txog kev kuaj ntshav neural mechanisms lub cev muaj zog hauv tsev homeostasis, qhov tseem ceeb ua haujlwm uas tswj cov kev ntsuas ntawm dej thiab ntsev hauv lub cev. Nws lub hom phiaj xav kom to taub txog kev ua pauv li cas thiab cov hauv paus hauv nruab nrab tswj kev haus dej haus cawv. Raws li lub hom phiaj no, nws pawg neeg tshawb fawb yuav muab cov kev siv lub cev thiab cov cuab yeej siv neev los piav qhia txog cov paj hlwb uas ua rau lub luag haujlwm tseem ceeb hauv kev tswj kev nqhis dej. Lawv mam li kuaj xyuas seb cov dej num ntawm cov circuits yog hloov los ntawm cov dej sab nraud. Nws txoj haujlwm ua rau muaj kev cuam tshuam rau kev kho mob tshiab rau kev noj qab haus huv ntawm kev noj qab haus huv.

Abigail Tus Neeg, Ph.D., Pab xibfwb txog Physiology thiab Biophysics, University of Colorado Denver

Circuit Court mechanisms ntawm cerebellar lub cev hloov kho

Kev txav yog qhov tseem ceeb rau txhua tus cwj pwm, tiam sis lub hlwb cov chaw tswj xyuas kev lag luam yog tsis to taub. Dr. Tus neeg ua hauj lwm tau tshawb pom tias lub hlwb ua rau kev taw qhia meej. Tus neeg lub hom phiaj yog xav tau tshwj xeeb tshaj plaws hauv lub paj hlwb hu ua cerebellum, nug nws seb nws cov teeb tseg puas yog kev tsav tsheb tsis tu ncua. Lub cerebellum tau tshwj xeeb tshaj yog txaus siab rau kev tshawb nrhiav Circuit Court vim nws cov khaubncaws sab nraud povtseg thiab lub xovtooj ntawm hom yog zoo heev txhais. Txawm li ntawd los, nws cov qauv tsim tawm, hu ua cerebellar nuclei, ua txhaum txoj cai no thiab ntau heterogeneous thiab li, ntau ntau ruam tag. Siv ntau hom physiological, optogenetic, anatomical thiab behavioral techniques, nws txoj kev tshawb nrhiav hom phiaj kom tsis txhob muaj qhov sib xyaw cov teeb meem ntawm cov nuclei los txhais tau tias nws txhawb rau kev tswj xyuas lub cev. Tus neeg cia siab tias nws txoj kev tshawb fawb tau muab tswv yim pab rau cov tswv yim kho mob rau cov neeg uas muaj tus kab mob cerebellar, thiab yuav muaj peev xwm pab cuam rau cov chav kawm ntawm cov cuab yeej siv uas siv cov cim neural los tswj kev nquag nquag.

Wei Wei, Ph.D., Pab xibfwb ntawm Neurobiology, University of Chicago

Dendritic ua ntawm kev tawm suab hauv qhov retina

Dr. Wei cov kev tshawb fawb nrhiav kom nkag siab txog lub hlwb cov cuab yeej ntawm cov lus tsa suab hauv lub retina. Cov theem pib ntawm qhov muag pom los ntawm lub hlwb tshwm sim nyob rau hauv retina, qhov chaw uas cov photons los ntawm lub ntiaj teb lub cev yog hloov mus rau hauv cov hlab ntsha pib hauv lub qhov muag. Ntau tshaj ib lub koob yees duab, lub zog retina zoo li lub computer me ntsis uas pib txheej txheem pom kev nkag mus rau hauv ntau cov dej ntws ntawm cov ntaub ntawv ua ntej mus txuas ntxiv rau cov chaw pom ntau dua hauv lub hlwb. Los ntawm kev kwv yees tam sim no muaj ntau dua 30 qhov kev sib tshuam neural nyob hauv lub retina, txhua qhov kev sib tw sib txawv, xws li kev ua ntawm kev sib tw, xim thiab qhov sib txawv. Dr. Wei lub (lab) yog siv cov qauv ntawm lub teeb los kawm txog seb tus retina txiav txim siab qhov kev coj ntawm cov lus tsa suab. Nws txoj haujlwm yuav qhia txog cov cai ntawm kev ua haujlwm ntawm kev sibtham thiab kev sibtham, thiab qhia txog cov ntsiab lus ntawm kev sib faib neural ntawm lub hlwb.


Susanne Ahmari, University of Pittsburgh 
Kev Paub Txog Neural Circuit Changes Cov Kev Hloov OCD Cov Cai Txog

Marlene Cohen, University of Pittsburgh
Causal thiab Correlative Tests ntawm Hypothesis uas yog Neuronal Mechanisms Cov Txheej Txheem Zoo Tshaj Tawm Txog Kev Sib Txeeb ntawm Cortical Cov Chaw 

Daniel Dombeck, Northwestern University
Functional Dynamics, Lub Koom Haum thiab Plasticiity ntawm Qhov Chaw Cell Dendritic Spines 

Surya Ganguli, Stanford University
Los ntawm Neural cov ntaub ntawv rau Neurobiological Kev nkag siab los ntawm Kev Sib Hlab thiab Kev Ntsuas Kub

Gaby Maimon, Rockefeller University
Neuronal Basis rau Lub Hauv Paus Pib Ua Haujlwm

Kay Tye, Massachusetts Lub Tsev Kawm Ntawv ntawm Tshuab 
Deconstructing cov Distributed Neural Mechanisms hauv Kev Ntsuam Xyuas Kev Ntsuas


Jessica Cardin, Yale University
Mechanisms ntawm Lub Xeev-Cortical Regulation

Robert Froemke, NYU Tsev Kawm Ntawv ntawm Tshuaj
Neural Circuitry thiab Plasticity rau Kev Tswj ntawm Mammalian Social Behaviour

Ryan Hibbs, UT Southwestern Kho Mob Chaw
Qauv thiab Mechanism ntawm Neuronal Acetylcholine Receptors

Jeremy Kay, Duke University
Sib dhos ntawm Retinal Direction-Selective Circuitry

Takaki Komiyama, UC San Diego 
Lub Cev Muaj Zog Cortex Plasticity nyob rau hauv Lub Cev Kev Kawm

Ilana Witten, Princeton University
Deconstructing Ua Haujlwm Nco Kev Ua Haujlwm: Dopamine Neurons thiab Lawv Cov Kev Ntsuas 


Hillel Adesnik, University of California-Berkeley
Optically Probing lub Neural Basis ntawm kev pom

Mark Churchland, Columbia University
Lub Neural Substrate ntawm Kev Koom Ua Yeem Dawb

Elissa Hallem, University of California - Los Angeles
Lub Koom Haum Ua Hauj Lwm ntawm Kev Ntsuas Hluav Taws Xob nyob rau hauv C.Elegans

Andrew Huberman, University of California - San Diego
Trans-Synaptic Circuits rau Kev Ua Cov Ncauj Lus Tshaj Tawm

Dayu Lin - NYU Langone Qhov Chaw Kho Mob
Lub Ceg Mechanism ntawm Lateral Septum Mediated Kev Ua Phem Txhaum

Nicole Rust - Tsev kawm ntawv ntawm Pennsylvania
Lub Neural Mechanisms Lub Luag Haujlwm Saib Xyuas Cov Khoom thiab Nrhiav Cov Hom Phaj


Anne Churchland, Khaub Hlis caij nplooj ntoos hlav Labor
Neural Circuits rau Kev Txiav Txim Siab Txiav Txim Siab

Patrick Drew, Pennsylvania State University
Kev Tsa Neurovascular Coupling hauv Behaving Tsiaj

David Freedman, University of Chicago
Neuronal Mechanisms ntawm Kev Categorization thiab Kev Txiav Txim Siab

Mala Murthy, Princeton University
Neural Mechanisms Cov Kev Sib Txuas Lus Hauv Kev Nyuaj Siab hauv Drosophila

Jonathan Pillow, University of Texas ntawm Austin
Deciphering Cortical Cov Neeg Sawv Cev ntawm Seem ntawm Spikes, Currents, thiab Kev Sib Tham

Vanessa Ruta, Rockefeller University
Lub Koom Haum Ua Hauj Lwm ntawm Kev Ua Hauj Lwm ntawm Neural Circuits Nqis Lus Qhia Ua Kev Nkag Siab 


Adam Carter, Ph.D., New York University
Synapse Kev Ntseeg Muaj nyob hauv Striatal Circuits

Sandeep Robert Datta, MD, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Neural Mechanisms Lub Cev Xeeb Tub Muaj Teeb Tseg

Qing Ntxuam, Ph.D., Columbia University
Molecular Mechanism of Metabotropic GABA Receptor Function

Ila Fiete, Ph.D., University of Texas, Austin
Cortical yuam kev-kev kho kom ze rau qhov sib piv

Winrich Freiwald, Ph.D., Rockefeller University
Los ntawm Face Recognition rau Social Cognition

Nathaniel Sawtell, Ph.D., Columbia University
Mechanisms rau Kev Ntsuas Kev Ntsuas Txog Hauv Cov Kab Xeem 


Anatol C. Kreitzer, Ph.D., J. David Gladstone Institutes
Function thiab kawg ntawm Basal Ganglia Circuits hauv Vivo

Seok-Yong Lee, Ph.D., Duke University Medical Center
Cov qauv thiab tshuaj ntawm cov sodium channel voltage sensors

Stavros Lomvardas, Ph.D., University of California
Molecular mechanisms ntawm olfactory receptor xaiv

Song-Hai Shi, Ph.D., Memorial Sloan-Kettering Cancer Center
Clonal ntau lawm thiab koom haum ua haujlwm hauv cov mammalian neocortex

Andreas S. Tolias, Ph.D., Baylor College of Medicine
Lub koom haum ua haujlwm ntawm lub cortical microcolumn 


Diana Bautista, Ph.D., University of California Berkeley
Molecular thiab Cellular Mechanisms ntawm Mammalian kov thiab mob

James Bisley, Ph.D., University of California Los Angeles
Lub luag haujlwm ntawm Cim Parietal Cortex hauv Cov Ntawv Qhia Kev Zoo thiab Kev Tawm Tsiaj

Nathaniel Daw, Ph.D., New York University
Kev Txiav Txim Siab hauv Kev Tsim Kho, Kev Ua Zoo Tshaj Plaub: Sib Sib Tham, Cwj Pwm, thiab Cov Tub Hluas Ntxhais Ncaj Ncees

Alapakkam Sampath, Ph.D., University of Southern California
Lub luag hauj lwm ntawm kev ua zoo nyob rau hauv Qhov Kev Xuas Hluav Taws Xob

Tatyana Sharpee, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Discrete Sawv Cev ntawm Kev Ntsuam Xyuas Hauv Cov Ntshav

Kausik Si, Ph.D., Lub Koom Txoos Kev Tshawb Fawb Txog Kev Kho Mob
Lub luag hauj lwm ntawm Prion-li Molecule hauv Persistence of Memory 


Jeremy Dasen, Ph.D., New York University School of Medicine
Mechanisms ntawm Synaptic Specificity nyob rau hauv Vertebrate Spinal Qaum

Wesley Grueber, Ph.D., Columbia University Medical Center
Dendritic Field Patterning los ntawm Cults Attractful thiab Repulsive

Greg Horwitz, Ph.D., University of Washington
Magnocellular kev koom tes rau xim ua

Coleen Murphy, Ph.D., Princeton University
Molecular Characterization ntawm Kev Tu Siab Ntev Nrog Lub Hnub Nyoog

Bence Olveczky, Ph.D., Harvard University
Kev Tawm Tsam Lub Koom Haum Txhim Kho ntawm Neural Circuits Nqaij Sensorimotor Kawm

Liam Paninski, Ph.D., Columbia University
Siv Cov Ntawv Tshaj Lij Cov Tshaj Lij rau Kev Sau Cov Cai Cuam Tshuam

Bijan Pesaran, Ph.D., New York University
Kev Txiav Txim Siab Qhov Twg thiab Qhov Twg Mus Qhov Twg 


Stephen A. Baccus, Ph.D., Stanford University Medical School
Functional Circuitry ntawm Neural Coding nyob hauv lub Retina

Karl A. Deisseroth, MD, Ph.D., Stanford University Medical School
Multi-Channel Ceev Laj Optical Interrogation ntawm Nyob ntawm Neural Circuitry

Gilbert Di Paolo, Ph.D., Columbia University Medical Center
Ib qho Kev Khiav Haujlwm Mus Ncaj Ncees rau Kev Sib Haum Haum Haum Hu Los ntawm PIP2 Metabolism hauv Synapse

Adrienne Fairhall, Ph.D., University of Washington
Intrinsic kev pabcuam rau Adaptive Computation thiab Kev Tswj Tau Txais

Maurice A. Smith, MD, Ph.D., Harvard University
Tus qauv ntawm kev sib raug zoo ntawm kev sib raug zoo rau kev piav qhia cov cuab yeej Short-term thiab Long-term Motor Learning

Fan Wang, Ph.D., Duke University Medical Center
Molecular thiab Genetic Analyzes ntawm Mammalian Touch Sensation

Rachel Wilson, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Lub Biophysical thiab Molecular Basis ntawm Central Synaptic Kis hauv Drosophila 


Thomas Clandinin, Ph.D., Stanford University Medical School
Yuav ua li cas Cov Kev Pom Zoo Citizen Cult Tau Tau Los Ntawm Kev Hloov Ntawm Cov Kev Lag Luam Neuronal?

James DiCarlo, MD, Ph.D., Massachusetts Lub Tsev Kawm Ntawv ntawm Tshuab
Neuronal Mechanisms Cov Khoom Taw Taw Taw Taw Thaum Lub Ntuj Saib

Florian Engert, Ph.D., Harvard University
Lub Neuronal Basis ntawm Kev Coj Tus Cwj Pwm Coj Ncig Hauv Larval Zebrafish

Youxing Jiang, Ph.D., University of Texas, Sab Qab Teb Kho Mob Center
Molecular Mechanisms ntawm Ion Selectivity hauv CNG Raws

Tirin Moore, Ph.D., Stanford University Medical School
Mechanisms ntawm Visuospatial Attention thiab Ua Haujlwm Nco

Hongjun Nkauj, Ph.D., Johns Hopkins University School of Medicine
Mechanisms Regulating Synaptic Integration ntawm Newly Generated Neurons nyob rau hauv Adult Lub Hlwb

Elke Stein, Ph.D., Yale University
Hloov kho Netrin-1-Mediated Attraction rau Kev Tawm Tseg Los ntawm Intracellular Crosstalk 


Athanossios Siapas, Ph.D., California Lub Tsev Kawm Ntawv Kev Tshawb Fawb
Cortico-Hippocampal Kev Sib Txawv thiab Kev Cim Nco Txog

Nirao Shah, MD, Ph.D., University of California, San Francisco
Sawv cev ntawm kev sib deev Dimorphic Behaviors hauv lub hlwb

Aravinthan Xamuyee, Ph.D., Harvard University
Lub Biophysical Approach rau Worm Behavioral Neuroscience

Bernardo Sabatini, MD, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Synaptic Kev Cai los ntawm Neuromodulatory Systems

Miriam Goodman, Ph.D., Stanford University
Nkag siab txog Force-Sensing Machinery ntawm kov Receptor Neurons

Matteo Carandini, Ph.D., Smith-Kettlewell Qhov muag tshawb nrhiav lub koom haum
Dynamics ntawm Population Response hauv Nrig Cortex 


Ricardo Dolmetsch, Ph.D., Stanford University
Kev Tsom Xam Ntawm Txoj Cai Ntawm Calcium Channel Proteome

Loren Frank, Ph.D., University of California, San Francisco
Lub Neural Correlates ntawm kev kawm nyob rau hauv lub Hippocampal - Cortical Circuit

Rachelle Gaudet, Ph.D., Harvard University
Cov Kev Txiav Txim Siab ntawm Cov Ntsuas Kub Teeb Tseg TRP Ion Channels

Z. Josh Huang, Ph.D., Khaub Hlis caij nplooj ntoos hlav Labor
Molecular Mechanisms Cov Txheej Txheem Qub Subcellular Targeting ntawm GABAergic Synapses

Kang Shen, MD, Ph.D., Stanford University
Nkag siab rau Code Code Molecular rau Lub Hom Phiaj Uas Muaj Kev Teeb Meem Hauv Synapse

David Zenisek, Ph.D., Yale University
Kev tshawb xyuas ntawm lub luag hauj lwm ntawm Synaptic Ribbon hauv Exocytosis 


Michael Brainard, Ph.D. University of California, San Francisco
Cwj Pwm thiab Neural Mechanisms ntawm Txoj Cai ntawm Cov Neeg Muaj Hnub Nyoog

Yausua Kub, Ph.D. Tsev kawm ntawv ntawm Pennsylvania Tsev Kawm Ntawv ntawm Cov Tshuaj
Lub Neural Basis ntawm kev txiav txim siab uas Txuas Txuas Txuas Txuas Thiab Ua

Jacqueline Gottlieb, Ph.D. Columbia University
Neural Substrates ntawm Tsom-iav thiab Tshaj Tawm rau Hauv Lub Nkuaj Pariant Parietal Cortex

Zhigang nws, Ph.D. Cov Menyuam Lub Tsev Kho Mob
Tshawb nrhiav Mechanisms ntawm Axon Regeneration tsis ua hauj lwm hauv Adult Control Nervous System

Kristin Scott, Ph.D. University of California, Berkeley
Saj Cov Sawv Cev hauv lub Drosophila Lub Ntsej Muag 


Aaron DiAntonio, MD, Ph.D., Washington University
Genetic Analysis ntawm Synaptic Kev Loj Hlob

Marla Feller, Ph.D., University of California, San Diego
Homeostatic Regulation of Spontaneous Kev Ua Lag Luam nyob hauv Kev Tsim Tus Mammalian Retina

Bharathi Jagadeesh, Ph.D., University of Washington
Cais ntawm lub Nres thiab Scene Selective Neurons nyob rau hauv lub Primate Inferotemporal Cortex

Bingwei Lu, Ph.D., Rockefeller University
Kev Coj Zoo Genetic Them rau Neural Stem Cell Behaviour

Philip Sabes, Ph.D., University of California, San Francisco
Lub Neural Mechanisms thiab Computational Principles ntawm Visuomotor Adaptation nyob rau hauv ncav

W. Martin Usrey, Ph.D., University of California, Davis
Muaj kev cuam tshuam Dynamics ntawm Feedforward thiab Cov Hom Hauj Lwm Kev Vam Meej 


Daniel Feldman, Ph.D., University of California, San Diego
Synaptic Hauv paus rau Whisker Daim Ntawv Qhia Hauv Daim Ntawv Cog Tseg Feem Hauv Nrawm Roj Cortex

Kelsey Martin, MD, Ph.D., University of California, Los Angeles
Kev Sib Txuas Lus Sib Dhos thiab Lub Xya Hli Thaum Lub Ntev Mus ntev Synaptic Txoj Cai

Daniel Minor, Jr., Ph.D., University of California, San Francisco
Kev tshawb fawb txog Kev Txiav Txim Siab ntawm Ion Channel

John Reynolds, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Neural Mechanisms kev Pom Nrig Feature Integration

Leslie Vosshall, Ph.D., Rockefeller University
Lub Molecular Biology Vev Vev Vev Lo rau hauv Drosophila

Anthony Wagner, Ph.D., Massachusetts Lub Tsev Kawm Ntawv ntawm Tshuab
Mechanisms ntawm Memory Formation: Prefrontal kev koom tes rau Episodic Encoding 


John Assad, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Ntev- thiab Lub Sij Hawm Lawm Lawm Lawm rau ntawm Encoding ntawm Pom Kev Pom Zoo nyob hauv Parietal Cortex

Eduardo Chichilnisky, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Xim thiab Paj Nrab Qab Sawm: Tshaj Xo Naj Npawb Los ntawm Lub Hom Phiaj Retina

Frank Gertler, Ph.D., Massachusetts Lub Tsev Kawm Ntawv ntawm Tshuab
Lub luag hauj lwm ntawm Cytoskeletal Regulatory Proteins hauv Axon Outgrowth thiab kev taw qhia

Jeffry Isaacson, Ph.D., University of California, San Diego
Synaptic Mechanisms ntawm Central Olfactory Circuits

Richard Krauzlis, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Kev sib koom tes ntawm Kev Pom Kev Pom Zoo ntawm Lub Pob Zeb Thoob Plaws (Superior Colliculus)

H. Sebastian Seung, Ph.D., Massachusetts Lub Tsev Kawm Ntawv ntawm Tshuab
Nco thiab Multistability nyob hauv kev tes hauj lwm

Jian Yang, Ph.D., Columbia University
Cov Tshuaj Pesticide Pestication thiab Gating Kawm nrog Cov Ntawv Cuam Tshuam Tshiab 


Michael Ehlers, MD, Ph.D., Duke University Medical Center
Molecular Regulation ntawm NMDA Receptors

Jennifer Raymond, Ph.D., Stanford University School of Medicine
Nyob rau hauv Vivo Physiological Analysis ntawm Mutations uas cuam tshuam Cerebellum-Nyob Txhaj Kawm

Fred Rieke, Ph.D., University of Washington
Muaj peev xwm tswj thiab Feativity selectivity ntawm Retinal Ganglion Hlav

Henk Roelink, Ph.D., University of Washington
Sonic Hedgehog Signal Transduction hauv Brain Malformations Induced by Cyclopamine

Alexander Schier, Ph.D., New York University School of Medicine
Mechanisms ntawm Forebrain Patterning

Paul Slesinger, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Kev qhia txog kev sib tham ntawm Molecular Kev Tshawb Fawb hauv G P Protein Tswj Kev Ua Piv Txwv

Michael Weliky, Ph.D., University of Rochester
Lub luag hauj lwm ntawm Correlated Neuronal Kev Ua Hauj Lwm hauv Kev Pom Kev Cortical


Paul Garrity, Ph.D., Massachusetts Lub Tsev Kawm Ntawv ntawm Tshuab
Axon Targeting hauv Drosophila Visual System

Jennifer Groh, Ph.D., Dartmouth College
Neural Coordinate Transformations

Phyllis Hanson, MD, Ph.D., Washington University School of Medicine
Lub luag hauj lwm ntawm Molecular Chaperones nyob rau hauv Presynaptic Function

Eduardo Perozo, Ph.D., University of Virginia Lub Tsev Kawm Ntawv ntawm Cov Tshuaj
High-Resolution Structural Studies ntawm K + Channel Pore

Wendy Suzuki, Ph.D., New York University
Tsav Chaw Haujlwm ntawm Macaque Parahippocampal Cortex


Ulrike I. Gaul, Ph.D., Rockefeller University
Cellular thiab Molecular Ib Feem ntawm Axon Cov Kev Qhia Ua nyob rau hauv ib qho yooj yim hauv Vivo System

Liqun Luo, Ph.D., Stanford University School of Medicine
Molecular Mechanisms ntawm Dendrite Development: Kev tshawb fawb ntawm GTPases Rac thiab Cdc42

Mark Mayford, Ph.D., University of California, San Diego
Tswj Genetic Control ntawm Synaptic Plasticity, Kawm, thiab Nco

Peter Mombaerts, MD, Ph.D., Rockefeller University
Mechanisms ntawm Axon kev taw qhia nyob rau hauv lub Olfactory System

Samuel L. Pfaff, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Kev Tiv Thaiv Mob Hlav Ntawm Lub Cev Hloov Cev Muaj Teeb Meem Neuron Axon Targeting

David Van Vactor, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Tsom xam ntawm cov noob uas Tswj Motor Axon kev taw qhia hauv Drosophila


Paul W. Glimcher, Ph.D., New York University
Neurobiological Raws li Kev Xaiv Tsa

Ali Hemmati-Brivanlou, Ph.D., Rockefeller University
Molecular Nam ntawm Vertebrate Neurogenesis

Donald C. Lo, Ph.D., Duke University Medical Center
Neurotrophin kev tswj ntawm Synaptic yas

Earl K. Miller, Ph.D., Massachusetts Lub Tsev Kawm Ntawv ntawm Tshuab
Kev Txawj Ua Ntej ntawm Prefrontal Cortex

Tito A. Serafini, Ph.D., University of California, Berkeley
Kev rho tawm thiab Characterization ntawm Kev Lom Zem Lub Hom phiaj Lub Cev Txhav

Jerry CP Yin, Ph.D., Khaub Hlis caij nplooj ntoos hlav Labor
CREB Phosphorylation thiab Kev Tsim Ntev ntawm Ntev Hauv Drosophila


Toshinori Hoshi, Ph.D., University of Iowa
Gating Mechanisms ntawm Voltage-dependent Potassium Channels

Alex L. Kolodkin, Ph.D., Johns Hopkins University School of Medicine
Molecular Mechanisms ntawm Kev Loj Hloov Txheej Txheem: Semaphorin Ua Haujlwm Thaum Lub Teeb Haujlwm Neurodevelopment

Michael L. Nonet, Ph.D., Washington University School of Medicine
Kev ntsuam xyuas caj ces ntawm kev loj hlob ntawm Neuromuscular Hlav

Mani Ramaswami, Ph.D., University of Arizona
Kev ntsuam xyuas kab mob Genetic ntawm Presynaptic Mechanisms

Michael N. Shadlen, MD, Ph.D., University of Washington
Kev Sib Koom Kev Sib Txawv thiab Kev Ua Haujlwm Nco

Alcino J. Silva, Ph.D., Khaub Hlis caij nplooj ntoos hlav Labor
Cellular Mechanisms Txhawb Nqes Cim Nco Txog Hauv Nas


Rita J. Balice-Gordon, Ph.D., Tsev kawm ntawv ntawm Pennsylvania
Yam Ntxim Saib Ntxim Ua Me Nyuam thiab Cov Nroj Ua Haujlwm Kev Sib Hlis Sab Nraud thiab Tsim Kho

Mark K. Bennett, Ph.D., University of California, Berkeley
Kev cai ntawm lub Synaptic Vesicle Docking thiab Fusion Machinery los ntawm Protein Phosphorylation

David S. Bredt, MD, Ph.D., University of California, San Francisco
Physiologic Functions ntawm Nitric Oxide nyob rau hauv kev Tsim Kho thiab Rov Qab Los Siv Neurons

David J. Linden, Ph.D., Johns Hopkins University School of Medicine
Ntawm Lub Cev Ntawm Cov Ntaub Ntawv Cia Hauv Lub Tsev Kawm Ntawv Cerebellum

Richard D. Mooney, Ph.D., Duke University Medical Center
Cellular Mechanisms ntawm Avian Vocal Learning thiab Memory

Charles J. Weitz, MD, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Molecular Biology ntawm Mammalian Circadian Pacemaker


Ben Barres, MD, Ph.D., Stanford University School of Medicine
Kev loj hlob thiab kev ua haujlwm ntawm Glia

Allison J. Doupe, MD, Ph.D., University of California, San Francisco
Lub Neural Circuit Specialized rau Vocal Kawm hauv Songbirds

Ehud Y. Isacoff, Ph.D., University of California, Berkeley
Kev tshawb fawb Molecular rau K + Channel Phosphorylation hauv Vertebrate Central Neurons

Susan K. McConnell, Ph.D., Stanford University School of Medicine
Kev rho tawm ntawm cov txheej txheej ntawm cov noob ntawm Mammalian Cerebral Cortex

John J. Ngai, Ph.D., University of California, Berkeley
Tsom xam ntawm Topography ntawm Cov Npe Hwj Haum Nefactory thiab Cov Lus Cog Tseg Cov Ntaub Ntawv

Wade G. Regehr, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Lub luag hauj lwm ntawm Presynaptic Calcium hauv yas nyob ntawm Central Synapses


Ethan Bier, Ph.D., University of California, San Diego
Molecular noob caj noob ces ntawm Neurogenesis

Linda D. Buck, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Neuronal Identity thiab Cov Lus Qhia Coding hauv Mammalian Olfactory System

Gian Garriga, Ph.D., University of California, Berkeley
Kev sib tshuam ntawm tes hauv qhov Outgrowth ntawm C.elegans HSN Axons

Roderick MacKinnon, MD, Tsev Kawm Ntawv Nruab Nrab Harvard
Subunit kev sib pauv hauv cov kua qaub (Channel)

Nipam H. Patel, Ph.D., Carnegie Institution of Washington
Lub luag hauj lwm ntawm Gooseberry thaum lub sij hawm Drosophila Neurogenesis

Gabriele V. Ronnett, MD, Ph.D., Johns Hopkins University School of Medicine
Lub Mechanisms ntawm Olfactory Signal Transduction

Daniel Y. Ts'o, Ph.D., Rockefeller University
Optical Imaging ntawm Neuronal Mechanisms ntawm Visual Behavior


Hollis T. Cline, Ph.D., University of Iowa Tsev Kawm Ntawv Kho Mob
Kev tswj ntawm Neuronal Loj hlob by Neurotransmitter thiab Protein Kinases

Gilles J. Laurent, Ph.D., California Lub Tsev Kawm Ntawv Kev Tshawb Fawb
Compartmentalization ntawm lub zos Neurons hauv Kab Sensory-cev tes hauj lwm

Ernest G. Peralta, Ph.D., Harvard University
Muscarinic Acetylcholine Receptor Signaling Pathways hauv Neuronal Hlav

William M. Roberts, Ph.D., University of Oregon
Ion Raws thiab Intracellular Calcium hauv Cov Plaub Hau

Thomas L. Schwarz, Ph.D., Stanford University School of Medicine
Cov noob caj noob ces ntawm VAMP thiab p65: Lub Dissection ntawm Transmitter Tso tawm hauv Drosophila

Marc T. Tessier-Lavigne, Ph.D., University of California, San Francisco
Purification, Cloning, thiab Characterization ntawm Chemoattractant uas Muaj Cov Tshwm Sim Kev Tshwm Sim nyob rau hauv Vertebrate Central Nervous System


John R. Carlson, Ph.D., Yale University School of Medicine
Molecular Organization ntawm lub Drosophila Olfactory System

Michael E. Greenberg, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Hluav Taws Xob Txhim Kho ntawm Cov Poj Suab Qhia Hauv Neurons

David J. Julius, Ph.D., University of California, San Francisco
Molecular Genetics ntawm Serotonin Receptor Function

Robert C. Malenka, MD, Ph.D., University of California, San Francisco
Mechanisms Kev Lees Paub Ncua Ntev hauv Hippocampus

John D. Sweatt, Ph.D., Baylor College of Medicine
Molecular Mechanisms rau LTP nyob rau hauv CA1 cheeb tsam ntawm Rat Hippocampus

Kai Zinn, Ph.D., California Lub Tsev Kawm Ntawv Kev Tshawb Fawb
Molecular Genetics ntawm Axon kev taw qhia nyob rau hauv Drosophila Embryo


Utpal Banerjee, Ph.D., University of California, Los Angeles
Neurogenetics ntawm R7 Cell Development hauv Drosophila

Paul Forscher, Ph.D., Yale University School of Medicine
Kev Teeb Meem Kev Hloov ntawm Neuronal Membrane-Qhov Chaw Haujlwm Interface

Michael D. Mauk, Ph.D., University of Texas Tsev Kawm Ntawv Kho Mob
Lub luag hauj lwm ntawm Protein Kinases nyob rau hauv Synaptic Kis thiab Cwj Pwm

Eric J. Nestler, MD, Ph.D., Yale University School of Medicine
Kev Cob Qhia ntawm Molus

Barbara E. Ranscht, Ph.D., La Jolla Cancer Research Foundation
Molecular Analysis of Chick Cell Surface Glycoproteins thiab Lawv Cov Hauj Lwm Hauv Qhov Caj Laj Fib Luam Hlob


Michael Bastiani, Ph.D., University of Utah
WKev Taw Qhia Kev Taw Qhia Ua Zoo Tshaj Plaws hauv Kev Ntsuas ntawm Kev Txhaum

Craig E. Jahr, Ph.D., Oregon Health & Science University
Molecular Mechanisms ntawm Excitatory Synaptic Kis

Christopher R. Kintner, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Molecular Basis ntawm Neural Induction hauv Amphibian Embryos

Jonathan A. Raper, Ph.D., University of Pennsylvania Qhov Chaw Kho Mob
Txheeb rau ntawm Molecules Muaj feem xyuam hauv Kev Tswj Cov Kev Loj Hlob Ntawm Kev Loj Hlob

Lorna W. Role, Ph.D., Columbia University College ntawm cov kws kho mob thiab cov kws phais
Modulation ntawm Neuronal Acetylcholine Receptors

Charles Zuker, Ph.D., University of California, San Diego
Cov Teeb Meem Kev Tawm Hauv Cov Nrig Zo Pom


Aaron P. Fox, Ph.D., University of Chicago
Hippocampal Calcium Raws: Biophysical, Pharmacological, thiab Functional Properties

F. Rob Jackson, Ph.D., Worcester Foundation rau Txoj Kev Ntsuas
Molecular Basis of Endogenous Timing Mechanisms

Dennis DM O'Leary, Ph.D., Washington University School of Medicine
Kev tshawb fawb ntawm Neocortical Development tsom rau ntawm qhov sib txawv ntawm qhov txawv

Tim Tully, Ph.D., Brandeis University
Molecular Cloning ntawm lub Drosophila Ntev-Ntig Memory Mutant Amnesiac thiab Nrhiav Tshawb Nrhiav Kev Txuas Ntev

Patricia A. Walicke, MD, Ph.D., University of California, San Diego
Hippocampal Neurons thiab Fibroblast Loj hlob


Christine E. Holt, Ph.D., University of California, San Diego
Axonal Pathfinding nyob rau hauv Vertebrate Embryo

Stephen J. Peroutka, MD, Ph.D., Stanford University School of Medicine
Kev Kho Mob Tshiab Kev Sib Txawv nrog Kev Kho Mob Central Serotonin Receptor Subtypes

Randall N. Pittman, Ph.D., Tsev kawm ntawv ntawm Pennsylvania Lub Tsev Kawm Ntawv ntawm Cov Tshuaj
Biochemical, Immunological, thiab Video Kev Txheeb ntawm Neurite Outgrowth

S. Lawrence Zipursky, Ph.D., University of California, Los Angeles
Molecular Genetic Approach rau Neural Connectivity


Sarah W. Bottjer, Ph.D., University of Southern California
Neuronal Mechanisms ntawm Vocal Development

S. Marc Breedlove, Ph.D., University of California, Berkeley
Andogenic Feem Cuam Tshuam Cov Kev Sib Txawv ntawm Neural Connections

Jane Dodd, Ph.D., Columbia University College ntawm cov kws kho mob thiab cov kws phais
Ntawm Mechanisms ntawm Kev Thoob Xob Kev Sib Hlwb nyob rau hauv Cutaneous Afferent Neurons

Haig S. Keshishian, Ph.D., Yale University School of Medicine
Kev Txiav Txim thiab Txawv ntawm Cov Peptidergic Neurons hauv Embryonic CNS

Paul E. Sawchenko, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Steroid-dependent yas nyob hauv Neuropeptide Expression


Ronald L. Davis, Ph.D., Baylor College of Medicine
Cyclic AMP System Noob thiab Nco hauv Drosophila

Scott E. Fraser, Ph.D., University of California, Irvine
Theoretical thiab Experimental Studies ntawm Nerve Patterning thiab Synaptic Competition

Michael R. Lerner, MD, Ph.D., Yale University School of Medicine
Nco thiab Olfaction

William D. Mathais, Ph.D., Harvard Cov Tsev Kawm Ntawv Kho Mob
Ib qho Kev Txhaj Tshuaj Tiv Thaiv thiab Txhaj Tshuaj Biochemical ntawm Proteoglycans nyob rau hauv Nervous System qhov Embryonic CNS

Jonathan D. Victor, MD, Ph.D., Cornell University Kev Kawm Txuj Ci
Ib qho kev soj ntsuam ntawm Evoked-teb ntawm Kev Pom Ib Nrab Hauv Kev Kho Mob thiab Kab Mob


Richard A. Andersen, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Nrig txog kev pom ntawm lub teeb ntawm lub teeb ntawm lub teeb ci ntsa iab ntawm lub Cim Parietal Cortex hauv Monkeys

Clifford B. Saper, MD, Ph.D., Washington University School of Medicine
Lub koom haum Cortical Arousal Systems

Richard H. Scheller, Ph.D., Stanford University School of Medicine
Kev soj ntsuam ntawm Kev Ua Haujlwm, Lub Koom Haum, thiab Daim Ntawv Qhia Kev Txiav Txim ntawm Neuropeptide Cov Neej hauv Aplysia

Mark Allen Tanouye, Ph.D., California Lub Tsev Kawm Ntawv Kev Tshawb Fawb
Molecular Biology ntawm Potassium Channel Genes nyob rau hauv Drosophila

George R. Uhl, MD, Ph.D., Massachusetts General Hospital
Nco txog Neurotransmitter Systems: Clinicopathological Correlation thiab Cov Kev Cai ntawm Cov Npe Cov Npe Sai


Bradley E. Alger, Ph.D., University of Maryland Lub Tsev Kawm Ntawv ntawm Cov Tshuaj
Kev Nyuaj Siab Kev Nyuaj Siab yuav pab txhawb kom muaj kev cia siab rau txoj kev tshawb fawb hauv cov Hipocampal Slice

Ralph J. Greenspan, Ph.D., Princeton University
Genetic and Immunological Studies ntawm Cell nto Molecules thiab lawv lub luag hauj lwm nyob rau hauv Neuronal kev loj hlob nyob rau hauv lub Nas

Thomas M. Jessell, Ph.D., Columbia University College ntawm cov kws kho mob thiab cov kws phais
Lub luag hauj lwm ntawm Neuropeptide nyob rau hauv Tej Kev Sib Tham thiab Kev Tsis Txaus Siab

Bruce H. Wainer, MD, Ph.D., University of Chicago
Cortical Cholinergic Innervation nyob rau hauv Health thiab kab mob

Peter J. Whitehouse, MD, Ph.D., Johns Hopkins University School of Medicine
Lub Anatomical / Pathological Basis ntawm lub Nco Kev Nyuaj Siab hauv Dementia


David G. Amaral, Ph.D., Salk lub koom haum rau kev tshawb fawb txog kev lom neeg
Kev tshawb fawb ntawm Kev Txhim Kho thiab Kev Sib Txuas ntawm Hippocampal

Robert J. Bloch, Ph.D., University of Maryland Lub Tsev Kawm Ntawv ntawm Cov Tshuaj
Macromolecules cuam tshuam nyob rau hauv Synapse Tsim

Stanley M. Goldin, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Reconstitution, Purification, thiab Immunocytochemical Localization ntawm Neuronal Ion Thauj Cov Proteins ntawm Mammalian Lub hlwb

Stephen G. Lisberger, Ph.D., University of California, San Francisco
Daim tawv nqaij ntawm Prestige Vestibulo-Ocular Reflex

Lee L. Rubin, Ph.D., Rockefeller University
Ntxawg Mechanisms nyob rau hauv cov hlab ntsha-Nqaij Synapse


Theodore W. Berger, Ph.D., University of Pittsburgh
Hlwb Lub Hlwb Hauv Cov Neeg Amnesia: Kawm ntawm Hippocampal-Subicular-Cingulate Cortical System

Thomas H. Brown, Ph.D., Lub Koom Haum Saib Xyuas Kev Cia Siab ntawm Lub Nroog
Quantal Analysis ntawm Synaptic Potentiation nyob rau hauv Hippocampal Neurons

Steven J. Burden, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Tus Synaptic Basal Lamina ntawm Kev Tsim thiab Rov Rov Qab Cov Paj Neuromuscular Synapses

Corey S. Goodman, Ph.D., Stanford University School of Medicine
Qhov Sib Piv Txwv, Kev Hloov Kho, thiab Kev Tuag Ntawm Tib Hlav Thaum Lub Zeem Muag Neuronal

William A. Harris, Ph.D., University of California, San Diego
Axonal kev taw qhia thiab Impulse kev ua hauv kev loj hlob


Robert P. Elde, Ph.D., University of Minnesota Tsev Kawm Ntawv Kho Mob
Immunohistochemical Kev tshawb fawb ntawm Limbic, Forbain, thiab Hypothalmic Peptidergic Hom

Yuh-Nung Jan, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Cov kev tshawb fawb txog Kev Nkoj Siv Los Siv Yav Dhau Los Siv Ua Lag Luam Ganglia Ua Qauv Qauv

Eva Marder, Ph.D., Brandeis University
Neurotransmitter Mechanisms ntawm Cov Ntaub Ntawv Leeg ntawm Cov Mob Hlwb Hauv Zuj Zus

James A. Nathanson, MD, Ph.D., Yale University School of Medicine
Hormone Receptor Mechanisms nyob rau hauv cov kev cai ntawm Cerebral ntshav Flow thiab Cerebrospinal kua Circulation

Louis F. Reichardt, Ph.D., University of California, San Francisco
Genetic Investigations ntawm Hlab Function hauv Kab lis kev cai


Linda M. Hall, Ph.D., Massachusetts Lub Tsev Kawm Ntawv ntawm Tshuab
Lub luag hauj lwm ntawm Cholinergic Synapses hauv Kev Kawm thiab Nco

Charles A. Marotta, MD, Ph.D., Tsev Kawm Ntawv Nruab Nrab Harvard
Kev Tswj ntawm Lub Hlwb Tubulin Synthesis Nyob Hauv Kev Loj Hlob

Urs S. Rutishauser, Ph.D., Rockefeller University
Lub luag hauj lwm ntawm Cell-Cell Adhesion hauv Kev Txhim Kho ntawm Neural Cov Hniav

David C. Spray, Ph.D., Albert Einstein College of Medicine
Neural Control ntawm Pub nyob rau hauv Navanax