Sanduuqa Awqaafta McKnight ee Neuroscience wuxuu doortay afar mashruuc si loo helo 2025 Neurobiology of Brain Disorders Awards. Abaalmarinada ayaa wadar ahaan doona $1.2 milyan oo cilmi baaris ah oo ku saabsan bayoolajiga cudurada maskaxda, iyadoo mashruuc kasta uu helayo $100,000 sanadkiiba seddexda sano ee soo socota wadar ahaan $300,000 oo la maalgeliyo mashruuc kasta.
Abaalmarinta Neurobiology ee Maskaxda Maskaxda (NBD) waxay taageertaa cilmi baaris cusub oo ay sameeyeen saynisyahano Mareykan ah oo baranaya cudurada neerfaha iyo maskaxda. Abaalmarinnadu waxay dhiirrigelinayaan iskaashiga u dhexeeya aasaasiga iyo daaweynta neerfaha si loo turjumo daahfurnaanta sheybaarka ee ku saabsan maskaxda iyo nidaamka neerfaha baaritaanka iyo daaweynta si loo wanaajiyo caafimaadka aadanaha.
Meel dheeraad ah oo xiisaha leh ayaa ah ka qayb qaadashada deegaanka ee cilladaha maskaxda. Cadaadiska deegaanka ee nolosha hore waa arrin awood badan oo meesha ka saarta xanuunnada neerfaha iyo maskaxda ee dambe. Daraasaduhu waxay muujinayaan bulshooyinka midabka leh inay halis sare ugu jiraan walaacyadan, kuwaas oo u dhexeeya deegaanka (sida cimilada, nafaqada, soo-gaadhista kiimikooyinka, wasakhowga) ilaa bulshada (sida qoyska, waxbarashada, guriyeynta, saboolnimada). Marka laga eego dhinaca bukaan-socodka, fahamka sida arrimaha deegaanku uga qaybqaataan cudurka maskaxda ayaa lagama maarmaan u ah horumarinta daawaynta waxtarka leh.
"Laga soo bilaabo dejinta hababka qallafsan ee hoos yimaada neurodegeneration si loo jaangooyo wareegga xanuunka iyo daah-furka sida soo-gaadhista aabuhu u qaabeeyaan caafimaadka maskaxda, cilmi-baarayaasha loo doortay abaalmarinta sanadkan waxay riixayaan xuduudaha neuroscience ee jihooyinka geesinimada leh iyo kuwa lagama maarmaanka ah," ayuu yiri Michael Ehlers, MD, Ph.D., Guddoomiyaha Guddiga Abaalmarinta BioM iyo Ganacsadaha GanacsigaImpa MP. "Mashruucyada sanadkan waxaa ka mid ah baaritaanada isdhexgalka-sare ee C9orf72-dhexdhexaadin ALS, cillad myelin ee cudurka Alzheimers, khariidadda wax soo saarka laf-dhabarka ee xanuunka, iyo, markii ugu horeysay tan iyo markii aan ku dhawaaqnay xoojintayada laba sano ka hor, mashruuc deegaan diiradda saaraya baaritaanka sida diiqada aabbuhu u saameeyaan faraca neerfayaasha si ay u beddelaan cudurka maskaxda ee maskaxda. mustaqbalka.”
Abaalmarinnada waxaa dhiirigeliyay danaha William L. McKnight, oo aasaasay Hay'adda McKnight Foundation 1953 oo doonayay inuu taageero cilmi-baarista cudurrada maskaxda. Gabadhiisa, Virginia McKnight Binger, iyo guddiga McKnight Foundation waxay aasaaseen barnaamijka McKnight neuroscience ee sharaftiisa 1977.
Abaalmarino badan ayaa la bixiyaa sanad walba. Afarta abaal marin ee sanadkan ayaa kala ah.
Hyejung Won, Ph.D., iyo isku-duwaha baaraha David Shechner, Ph.D.
(Wuxuu Guulaystay) Associate Professor, Genetics, Jaamacadda North Carolina School of Medicine
(Shechner) Kaaliyaha Professor, Farmaajoloji, Jaamacadda Washington, Seattle, Washington
Go'aaminta isdhexgalka nidaamka sare ee C9orf72-dhexdhexaadinta ALS
Upasna Sharma Ph.D.
Kaaliyaha Professor, Molecular, Cell, iyo Biology Koriinka, Jaamacadda California, Santa Cruz, California
Wax ku biirinta deegaanka aabbaha ee habacsanaanta cadaadiska ee faraca
Allan-Hermann Pool, Ph.D.
Kaaliyaha Professor, Neuroscience, Jaamacadda Texas Southwestern Medical Center, Dallas, Texas
Tilmaamaha iyo bartilmaameedka daaweynta ee khariidadda soosaarka laf dhabarta ee xaaladaha xanuunka
Brad Zuchero, Ph.D. iyo la- maamulaha baaraha Ethan Hughes, Ph.D.
(Zuchero) Caawiyaha Professor, Neurosurgery, Jaamacadda Stanford, Stanford, California
(Hughes) Associate Professor, Cell & Biology Kobcinta, Jaamacadda Colorado Anschutz Medical Campus, Aurora, Colorado
Myelin cillad la'aanta miyuu keenaa cudurka Alzheimers?
Iyadoo 182 warqadood oo ujeedo ah la helay sanadkan, abaal-marintu waa tartan heer sare ah. Guddi saynisyahano ah oo caan ah ayaa dib u eegis ku sameeya xarfaha oo ku casuumay dhowr cilmi-baarayaal si ay u soo gudbiyaan soo jeedin buuxda. Marka lagu daro Dr. Ehlers, guddiga waxaa ka mid ah Nicole Calakos, MD, Ph.D., Jaamacadda Duke; Gloria Choi, Ph.D., Massachusetts Institute of Technology; André Fenton, Ph.D., Jaamacadda New York; Joseph G. Gleeson, MD, Jaamacadda California San Diego; Tom Lloyd, MD, Ph.D., Baylor College of Medicine; iyo Michael Shadlen, MD, Ph.D., Jaamacadda Columbia.
Codsiyada labadaba 2026 Neurobiology of Brain Disorders Awards iyo Abaalmarinta Aqoonyahanka ayaa furmay Ogosto 1, 2025.
Ku saabsan Sanduuqa Maaliyadda ee McKnight Fund for Neuroscience
Sanduuqa Endowment Fund ee McKnight ee Neuroscience waa urur madax-bannaan oo ay maalgeliso oo keliya McKnight Foundation ee Minneapolis, Minnesota, oo ay hoggaamiyaan guddi ay ku jiraan saynisyahano caan ah oo ka kala yimid dalka oo dhan. Mu'asasada McKnight waxay taageertay cilmi-baarista neuroscience tan iyo 1977. Aasaaska ayaa aasaasay Sanduuqa Awqaafta 1986 si loo fuliyo mid ka mid ah ujeedooyinka aasaasaha William L. McKnight (1887-1978), mid ka mid ah hoggaamiyeyaashii hore ee Shirkadda 3M.
Marka laga soo tago Abaalmarinta Cilmi-nafsiga ee Xanuunnada Maskaxda, sanduuqa hibaynta waxa kale oo ay bixisaa maalgelin abaal-marin sanadle ah iyada oo loo marayo Abaalmarinnada Aqoonyahannada McKnight, oo taageeraya saynisyahannada neerfaha marxaladaha hore ee xirfadahooda cilmi-baarista.
Abaalmarinta Neurobiology ee Abaalmarinta Maskaxda
Hyejung Won, Ph.D., Professor Associate, Genetics, Jaamacadda North Carolina School of Medicine, iyo kormeeraha maamulaha David Shechner, Ph.D., Kaaliyaha Professor, Pharmacology, Jaamacadda Washington, Seattle, Washington
Go'aaminta isdhexgalka nidaamka sare ee C9orf72-dhexdhexaadinta ALS
Amyotrophic lateral sclerosis (ALS) waa cillad neurodegenerative dilaa ah oo lagu garto luminta joogtada ah ee neerfayaasha dareemayaasha iyo daciifnimada murqaha. Noocyada ALS ee la dhaxlo waxay inta badan ku xiran yihiin fidinta aan caadiga ahayn ee taxanaha DNA-ga gaaban-oo loo yaqaanno soo noqnoqda gaaban ee gaaban (STRs) - ee ku jira hidda-wadaha C9orf72. Inkasta oo xidhiidhkan cad ee hidde-sidaha, horumarinta daawaynta waxtarka leh ee C9orf72-dhexdhexaadinta ALS ay ahayd mid adag sababtoo ah kakanaanta hababkeeda hoose.
C9orf72-dhexdhexaadin ALS waxay ku lug leedahay habab cudur oo kala duwan, oo ay ku jiraan RNA sunta ah iyo borotiin-dhisidda. Caddaynta soo baxday waxay sidoo kale soo jeedinaysaa in balaadhinta STR laga yaabo inay carqaladayso sida DNA-da loogu ururiyo unugyada, laakiin hababka saxda ah ee unugyada ayaa si liidata loo fahmay. Drs. Hyejung Won iyo David Shechner waxay ujeedadoodu tahay inay adeegsadaan qalabka hidda-socodka iyo kiimikaalka bayoolajiga si loo ogaado sida C9orf72 STR ballaarinta ay dib ugu qaabeeyaan qaab dhismeedka DNA-da oo ay gacan uga geystaan pathology ALS.
Upasna Sharma, Ph.D., Kaaliyaha Professor, Molecular, Cell, iyo Biology Koriinka, Jaamacadda California, Santa Cruz, California
Wax ku biirinta deegaanka aabbaha ee habacsanaanta cadaadiska ee faraca
Soo-gaadhista aabbaha ee walaaca ma qaabayn karaa bayoloji carruurtiisa? Cadeymaha soo baxaya ayaa muujinaya inay awoodaan. Cilmi-baadhisyada cudurrada faafa waxay isku xidhaan walbahaarka aabbaha iyo waayo-aragnimada nololeed ee xun iyo khatarta sii kordheysa ee cudurrada neerfayaasha maskaxda ee faraca, haddana hababka ayaa ah kuwo si liidata loo fahmay. Cilmi-baarista Dr. Sharma waxay ujeedadeedu tahay inay wax ka qabato farqigan iyadoo la baarayo sida diiqada joogtada ah ee jiirarka labka ah ay u beddelaan shahwada iyo barnaamijyada walaaca dysregulation ee faraca.
Shaybaarkeeda waxa ay ogaatay in lab-laakin aan dhedig ahayn—farcanka aabbayaasha walaaca leh ay muujiyaan jawaabaha walbahaarka oo aan caddayn, sifo la xidhiidha xanuunnada dhimirka qaarkood. Dr. Sharma waxa uu hiigsanayaa in uu daaha ka qaado calaamadaha molecular ee ka dambeeya dhaxalka noocaas ah, isaga oo diiradda saaraya unugyada RNA yar ee ku jira shahwada. Shaybaarkeeda ayaa kala saari doona sida calaamadaha cadaadiska maskaxda looga gudbiyo shahwada iyo sida calaamadahani u saameeyaan horumarka hore si ay u saameeyaan caafimaadka ilmaha. Cilmi-baaristan waxay ujeedadeedu tahay inay bixiso aragti cusub oo ku saabsan xididdada bayooloji ee khatarta cudurrada la xiriira walaaca.
Allan-Hermann Pool, Ph.D., Kaaliyaha Professor, Neuroscience, Jaamacadda Texas Southwestern Medical Center, Dallas, Texas
Tilmaamaha iyo bartilmaameedka daaweynta ee khariidadda soosaarka laf dhabarta ee xaaladaha xanuunka
Xanuunku waa nidaam dhiirigelin ah oo nagu qasbaya inaan ka fogaano waxyeellada jirka oo u beddeleysa ogaanshaha dhaawacyada si looga fogaado la qabsiga, la qabsiga iyo dabeecadaha barashada. Iyadoo xanuunku uu muhiim u yahay badbaadada, ka-hortagga xanuunka wuxuu u horseedi karaa xanuun dabadheeraad ah kaas oo weli ah culeys caafimaad oo dadweyne oo cabsi leh. Qaybaha gacanta ee sababa xanuunka joogtada ah ee dhexe iyo macneheedu waa in si door ah loo xakameeyo iyaga si liidata loo qeexo. Shaqadii hore, shaybaarka Pool wuxuu aqoonsaday xudunta laf-dhabarka neuronal repertoires kuwaas oo ay wadaan dhaawacyo dusha kala duwan iyo unugyada qoto dheer oo tilmaamaya musharraxiinta neerfaha ee xanuunka.
Shaqada cusub, shaybaarka Pool wuxuu ujeedkiisu yahay inuu caddeeyo doorka sababta xanuunka ee qanjidhada wareegga laf-dhabarka ee habka xanuunka. Intaa waxaa dheer, waxay raadinayaan inay horumariyaan istaraatiijiyad cusub oo ku salaysan immunotoxin si ay degaanka u baabi'iyaan xanuunka dhexdhexaadinta unugyada laf-dhabarka oo ay ku bixiyaan xal daaweyneed oo hal-maamul ah oo loogu talagalay maaraynta xanuunka.
Brad Zuchero, Ph.D., Kaaliyaha Professor, Neurosurgery, Jaamacadda Stanford, Stanford, California, iyo baaraha la-shaqeeyaha Ethan Hughes, Ph.D., Professor Associate, Cell & Biology Koriinka, Jaamacadda Colorado Anschutz Medical Campus, Aurora, Colorado
Myelin cillad la'aanta miyuu keenaa cudurka Alzheimers?
Myelin waxaa looga baahan yahay si degdeg ah oo sax ah calaamadaha neerfaha wuxuuna ka ciyaaraa door muhiim ah ilaalinta neerfaha, barashada, iyo xusuusta. Cilad la'aanta Myelin iyo luminta ayaa soo ifbaxday sida calaamadaha hore ee cudurrada neerfayaasha, oo ay ku jiraan cudurka Alzheimers (AD). Si kastaba ha ahaatee, hababka gacanta ee kaxeeya cillad la'aanta myelin-ka iyo luminta AD ayaa weli ah mid aan la garanayn.
Si wada jir ah, shaybaarka Zuchero iyo Hughes waxay isticmaali doonaan jiirka adag ee hidde-sideyaasha-dheellida dhuumaha phenotyping myelin si loo qeexo saamaynta hiddo-wadaha AD-ku-xidhan ee muhiimka ah samaynta iyo daacadnimada myelin. Mashruucu waxa uu ka faa'iidaysan doonaa khibrada dhamaystirka ah ee shaybaadhka Zuchero ee bayoolojiga unugga myelin-ka iyo dhismaha qalabka hidaha, iyo shaybaadhka Hughes ee ku-meel-gaadhka ah ee vivo sawirka samaynta myelin-ka/dhaqdhaqaaqa iyo qiimaynta dabeecadda.
Guud ahaan, mashruucani waxa uu raadinayaa in uu furo aag soo baxaya oo cilmi-baaris AD ah oo laga yaabo in ay daaha ka qaado myelin oo ah bartilmaameed cusub oo daaweyn ah oo aan la taaban - hadaf cilmi-baariseed oo isbeddel ah oo shaybaarada Zuchero iyo Hughes ay diyaar u yihiin inay si wadajir ah wax uga qabtaan.
